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Black male tuberculosis patients (106) were phenotyped into 59% fast and 41% slow acetylators with isoniazid (NH) plasma half-lives. The antimode time dividing the two acetylator groups was longer than that previously reported for Whites. The therapeutic significance of INH acetylator phenotyping per se is questioned since it provides neither a measurement(More)
Plasma cephradine levels were measured after parenteral and oral administration to healthy adults. Plasma cephradine contrations of 7 - 15 mug/ml were measured after 0.5 g had been administered by mouth, and concentrations of 12 - 57 mug/ml were measured after parenteral administration; they fell to 3 mug/ml within 240 minutes except after intramuscular(More)
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