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Malignant rhabdoid tumors (MRT) are characterized by a typical light microscopic morphology with uniformly round tumor cells, vacuolated cytoplasm with occasional round, hyaline intracytoplasmic, periodic acid-Schiff-positive inclusions, vesicular nuclei with prominent nucleoli and positive immunoreactivity for vimentin. The histogenesis of MRT is(More)
Pathologic findings are presented in a case of neurodegenerative disease with a 5-year course of progressive presenile dementia and parkinsonism. At autopsy, atrophy of the cerebral cortex, caudate nucleus, and substantia nigra were observed. Homogeneous eosinophilic intracytoplasmic neuronal inclusions were found, predominantly in the brainstem and(More)
PURPOSE Primary malignant rhabdoid tumor (MRT) of the central nervous system is an extremely aggressive tumor predominantly related to early childhood, with characteristic histopathological findings but unclear histogenesis. Owing to its low incidence, little knowledge exists concerning the best therapeutic strategy. METHODS AND MATERIALS Three children(More)
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