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Surface proteins are important factors in the interaction of probiotic and pathogenic bacteria with their environment or host. We performed a comparative bioinformatic analysis of four publicly available Lactobacillus genomes and the genome of Lactobacillus salivarius subsp. salivarius strain UCC118 to identify secreted proteins and those linked to the cell(More)
BACKGROUND The incidence of atopic disease has increased dramatically during recent decades and the potential immunoregulatory influence of the microbiota in these individuals is under investigation. OBJECTIVE The aim of our study was to identify a bacterial strain that is protective in murine allergy models and to determine if microbial induction of T(More)
Most innovations in programming languages and methodology are motivated by a belief that they will improve the performance of the programmers who use them. Although such claims are usually advanced informally, there is a growing body of research which attempts to verify them by controlled observation of programmers' behavior. Surprisingly, these studies(More)
  • J McCarthy, L O'Mahony, +8 authors F Shanahan
  • 2003
BACKGROUND Prophylactic efficacy against colitis following lactobacillus consumption in interleukin 10 (IL-10) knockout (KO) mice has been reported. Whether this applies equally to other probiotic strains is unknown, and the mechanism is unclear. AIMS (1) To compare the effect of feeding Lactobacillus salivarius subspecies salivarius 433118 and(More)
BACKGROUND We and others have reported the prophylactic efficacy of oral consumption of probiotic lactobacilli in the interleukin 10 knockout (IL-10 KO) model of colitis. It has not been demonstrated that the oral route is essential for probiotic efficacy. AIMS (i) To determine the effect of parenteral administration (subcutaneous) of Lactobacillus(More)
Components of the commensal flora, including Bifidobacteria and Lactobacilli, have been associated with beneficial effects on the host. These beneficial effects include maintenance of intestinal homeostasis, competitive exclusion of pathogens, production of antimicrobial compounds, promotion of gut barrier function, and immune modulation. Probiotics(More)
INTRODUCTION Clostridium difficile is an increasing cause of nosocomial diarrhoea and colitis. The aim of this study was to identify the prevalence and characteristics of asymptomatic C. difficile carriage in a continuing care institution for the elderly. METHODS Stool samples were collected from 100 asymptomatic patients, whose median age was 83 years.(More)
Split trees are a new technique for searching sets of keys with highly skewed frequency distributions. A split tree is a binary search tree each node of which contains two key values&#8212;a <italic>node</italic> value which is a maximally frequent key in that subtree, and a <italic>split</italic> value which partitions the remaining keys (with respect to(More)
Heterogeneity of dendritic cells (DC) is evident in the gut-associated lymphoid tissue and determined, in part, by incompletely understood local environmental factors. Bacterial signalling is likely to be a dominant influence on precursor cells when recruited to the mucosa. We assessed the influence of commensal bacteria on DC differentiation and function.(More)
BACKGROUND Human intestinal epithelial cells (IECs) secrete the chemokine CCL20 in response to infection by various enteropathogenic bacteria or exposure to bacterial flagellin. CCL20 recruits immature dendritic cells and lymphocytes to target sites. Here we investigated IEC responses to various pathogenic and commensal bacteria as well as the modulatory(More)