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Treatment of NG108-15 cells with bradykinin for 10 min resulted in a reduction of phosphatidylinositol levels with no change in the other inositol lipids. Accompanying this was a small increase in diacylglycerol but no modification in the level of inositol phosphates. Addition of bradykinin to cells incubated for 30 min in buffer containing lithium did not(More)
Exposure of bovine adrenocortical cells to optimal concentrations of angiotensin II (A II) resulted in an almost 2-fold enhancement of cellular cAMP accumulation in response to steroidogenic concentrations of ACTH. This effect was dose-dependent and transient, with a maximum after 4-6 min of treatment with A II. Activators of protein kinase C such as(More)
Previous studies have shown that in the neuroblastoma x glioma hybrid cell line NG108-15 lithium is able to induce an increase in diacylglycerol levels. This effect was shown to be enhanced by the presence of bradykinin. Another striking effect of lithium was a marked gain in the level of the liponucleotide phosphatidyl-CMP. Increased phosphatidyl-CMP(More)
Thrombomodulin and tissue factor activities have been co-extracted from human placenta by several non-ionic detergents, n-octylglucoside and Triton X-100 being the most efficient ones. The n-octylglucoside placenta extract had a strong cofactor activity in the activation of human protein C by human alpha-thrombin. Treatment of the n-octylglucoside and(More)
Protein kinase C is expressed in adrenal cortex as a single isoenzyme, whereas four isoforms are detected in brain tissue. Of the two major steroidogenic agents (ACTH and angiotensin II), only A II stimulates polyphosphoinositide hydrolysis and thus appears able to induce protein kinase C activation in adrenocortical cell. Although direct activation of the(More)
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