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Determinations of albumin and immunoglobulin G (IgG) were performed in paired cerebrospinal fluid (CSF) and serum samples from 24 subjects with schizophrenia. These determinations allowed calculation of two indices, one that is an indicator of integrity of the blood-brain barrier and the other a measure of selective IgG production within the central nervous(More)
A 2-year prophylactic trial was carried out in 31 bipolar manic-depressive subjects, comparing 300 mg/day methylene blue on a double-blind crossover basis with 15 mg/day. All patients were also maintained on lithium. Seventeen patients completed the 2-year trial. During the year the patients were treated with methylene blue at 300 mg/day, they were(More)
S chizophrenia and affective psychoses are severe and prevalent psychiatric disorders described in all cultures and populations. Whether these functional psychoses are two distinct disorders, or are closely related in aetiology, has been debated in the literature during the last century. Several studies have suggested that schizophrenia and bipolar disorder(More)
Background.  Although acquired immune deficiency syndrome-associated morbidity has diminished due to excellent viral control, multimorbidity may be increasing among human immunodeficiency virus (HIV)-infected persons compared with the general population. Methods.  We assessed the prevalence of comorbidities and multimorbidity in participants of the Swiss(More)
As part of a survey of 1011 men aged 20-60 years, a factor analysis and validation study of the General Health Questionnaire (GHQ) was carried out. Three clinically relevant factors could be isolated but factor analysis did not generally enhance the value of the GHQ. When compared with results for a similar group of women, sex differences in answering the(More)
A survey of men aged from 20 to 59 years from a general practice list using the General Health Questionnaire and a questionnaire of social and domestic items yielded 1011 respondents. Several items were shown to be linked with psychological disturbance including ill health, ill health or psychiatric history in wife, poor relationship with wife, being(More)
BACKGROUND IMAGe provides information on risks and benefits of medication use during pregnancy and lactation. OBJECTIVE The aim of this study was to determine the impact of Health Canada warnings on the number of calls received at IMAGe. METHODS We analyzed calls received between January 2003 and March 2008. The impact of the following(More)
A genetic subtype of schizophrenia has been described in 22q11 Deletion syndrome. Previous studies have described an excess of dermatoglyphic alterations in schizophrenia, such as low a-b ridge counts (ABRCs), a high frequency of ridge dissociations, and increased dermatoglyphic fluctuating asymmetry. Little is known however, about the dermatoglyphic(More)
Indalpine 150 mg per day and mianserin 60 mg per day were compared in a double-blind study of 65 depressed out-patients: 52 patients completed the 4-week trial. At the end of four weeks there was no significant difference in antidepressant effect between the two drugs; but in the first two weeks, improvement in the mianserin-treated group was significantly(More)
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