Aziz H. Poonawalla

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BACKGROUND AND PURPOSE Accurate detection and classification of purely intracortical lesions in multiple sclerosis (MS) are important in understanding their role in disease progression and impact on the clinical manifestations of the disease. However, detection of these lesions with conventional MR imaging remains a challenge. Although double inversion(More)
BACKGROUND Gray matter lesions are known to be common in multiple sclerosis (MS) and are suspected to play an important role in disease progression and clinical disability. A combination of magnetic resonance imaging (MRI) techniques, double-inversion recovery (DIR), and phase-sensitive inversion recovery (PSIR), has been used for detection and(More)
PURPOSE To develop an analytical formalism describing how noise and selection of diffusion-weighting scheme propagate through the diffusion tensor imaging (DTI) computational chain into variances of the diffusion tensor elements, and errors in the relative anisotropy (RA) and fractional anisotropy (FA) indices. MATERIALS AND METHODS Singular-value(More)
BACKGROUND Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples. OBJECTIVE To explore the correlation of(More)
PURPOSE To validate adipose tissue magnetic resonance imaging (atMRI) for rapid, quantitative volumetry of visceral adipose tissue (VAT) and total adipose tissue (TAT). MATERIALS AND METHODS Data were acquired on normal adults and clinically overweight girls with Institutional Review Board (IRB) approval/parental consent using sagittal 6-echo 3D-spoiled(More)
PURPOSE To prospectively perform a direct measurement of fractional anisotropy (FA) and mean diffusivity (MD) in cortical lesions of patients with multiple sclerosis (MS). MATERIALS AND METHODS The study was approved by the institutional review board and was HIPAA compliant; informed consent was obtained. Magnetic resonance (MR) images, including double(More)
BACKGROUND AND OBJECTIVES Based on the application of newer magnetic resonance imaging (MRI) acquisition sequences, the detection of cortical lesions (CL) in multiple sclerosis (MS) has significantly improved. Double inversion recovery (DIR) at 3T has increased the detection sensitivity and classification specificity when combined with phase sensitive(More)
F. Nelson A.H. Poonawalla P. Hou F. Huang J.S. Wolinsky P.A. Narayana BACKGROUND AND PURPOSE: Accurate detection and classification of purely intracortical lesions in multiple sclerosis (MS) are important in understanding their role in disease progression and impact on the clinical manifestations of the disease. However, detection of these lesions with(More)
An algorithm for correcting the geometric distortions in the echo planar images and diffusion weighted images is described. In this method the geometric distortion in the echo planar imaging (EPI) data is corrected by non-rigid registration to conventional fast-spin echo (FSE) images. The registration is based on a variant of the Demon's algorithm [10] with(More)
Z-P. Liang, A. H. Poonawalla, D. Hernando, L. Ying, X. J. Zhou Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States, Department of Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, Texas, United States, Department of Electrical Engineering and Computer Science,(More)