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Masked volume wise principal component analysis of small adrenocortical tumours in dynamic [11C]-metomidate positron emission tomography

• Pasha Razifar, Joakim Hennings, Azita Monazzam, Per Hellman, Bengt Långström, Anders Sundin
• BMC Medical Imaging
• 2009

BACKGROUND In previous clinical Positron Emission Tomography (PET) studies novel approaches for application of Principal Component Analysis (PCA) on dynamic PET images such as Masked Volume Wise PCA… (More)

Evaluation of the Hsp90 inhibitor NVP-AUY922 in multicellular tumour spheroids with respect to effects on growth and PET tracer uptake.

• Azita Monazzam, Pasha Razifar, +5 authors Mats Bergström
• Nuclear medicine and biology
• 2009

BACKGROUND Molecular targeting has become a prominent concept in cancer treatment and heat shock protein 90 (Hsp90) inhibitors are suggested as promising anticancer drugs. The Hsp90 complex is one of… (More)

Non-hybridization saturable mechanisms play a role in the uptake of (68)Ga-Labeled LNA-DNA mixmer antisense oligonucleotides in rats.

• Gábor Lendvai, Azita Monazzam, +5 authors Sergio Estrada
• Oligonucleotides
• 2009

Oligonucleotides (ODN) are key molecules for the aim of preventing translation of a gene product or monitoring gene expression in tissues. However, multiple methodological and biological hurdles need… (More)

Signal extraction and separation in in vivo animal PET studies with masked volumewise principal-component analysis.

• Fredrik Engbrant, Azita Monazzam, P. Svensson, J. -E. Olsson, Ewert Bengtsson, Pasha Razifar
• Journal of nuclear medicine technology
• 2010

UNLABELLED The standardized uptake value is commonly used as a tool to supplement visual interpretation and to quantify the images acquired from static in vivo animal PET. The preferred approach for… (More)

Modeling spheroid growth, PET tracer uptake, and treatment effects of the Hsp90 inhibitor NVP-AUY922.

• Mats Bergstrom, Azita Monazzam, Pasha Razifar, Susan E. Ide, Raymond Josephsson, Bengt Långstrom
• Journal of nuclear medicine : official…
• 2008

UNLABELLED For a PET agent to be successful as a biomarker in early clinical trials of new anticancer agents, some conditions need to be fulfilled: the selected tracer should show a response that is… (More)

Multicellular Tumour Spheroid as a model for evaluation of [18F]FDG as biomarker for breast cancer treatment monitoring

• Azita Monazzam, Pasha Razifar, +5 authors Mats Bergström
• Cancer Cell International
• 2005

In order to explore a pre-clinical method to evaluate if [18F]FDG is valid for monitoring early response, we investigated the uptake of FDG in Multicellular tumour spheroids (MTS) without and with… (More)

Dopaminergic effects after chronic treatment with nandrolone visualized in rat brain by positron emission tomography.

• Anna M S Kindlundh, Mats Bergström, +4 authors Fred J Nyberg
• Progress in neuro-psychopharmacology & biological…
• 2002

Anabolic-androgenic steroids (AAS) have recently been shown to induce neurochemical alterations in areas of the male rat CNS related to behavioural changes that have been observed among AAS misusers.… (More)

In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multifunctional antibody TF2 and (67/68Ga)-labeled haptens by pretargeting.

• H Irene Hall, Irina Velikyan, +8 authors Bengt Långström
• American journal of nuclear medicine and…
• 2012

The carcinoembryonic antigen (CEA) was visualized in vitro in tissue from patients with colorectal cancer with trivalent bispecific antibody TF2 and two hapten molecules, [(67/68)Ga]Ga-IMP461 and… (More)

Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer

• Azita Monazzam, Raymond Josephsson, Carl Blomqvist, Jörgen Carlsson, Bengt Långström, Mats Bergström
• Breast Cancer Research
• 2007

Positron emission tomography (PET) is suggested for early monitoring of treatment response, assuming that effective anticancer treatment induces metabolic changes that precede morphology alterations… (More)

Increased Expression of GLP-1R in Proliferating Islets of Men1 Mice is Detectable by [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 /PET

• Azita Monazzam, Joey Lau, +5 authors Britt M Skogseid
• Scientific Reports
• 2017

Multiple endocrine neoplasia type 1 (MEN1) is an endocrine tumor syndrome caused by heterozygous mutations in the MEN1 tumor suppressor gene. The MEN1 pancreas of the adolescent gene carrier… (More)

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