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The cellular function of the intrinsic prion protein (PrPc) remains largely unknown. In the present study PrPc expression was investigated in multicellular prostate tumor spheroids and was correlated… (More)
The presence of the prion protein (PrP) in normal human urine is controversial and currently inconclusive. This issue has taken a special relevance because prion infectivity has been demonstrated in… (More)
Transmissible spongiform encephalopathies are a group of infectious diseases typically associated with the accumulation of a protease-resistant and beta-sheet-rich prion protein, PrPSc, in affected… (More)
Prion diseases are neurodegenerative conditions associated with a misfolded and infectious protein, scrapie prion protein (PrP(Sc)). PrP(Sc) propagate prion diseases within and between species and… (More)