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Measurement of pulse wave velocity (PWV) is a useful approach for evaluating the severity of atherosclerosis in adults, and, in particular, the measurement of brachial–ankle PWV (baPWV) has been commonly reported as a simple and practicable method. We attempted to investigate how baPWV in healthy children changes with age and gender, in order to assess(More)
OBJECTIVE To study the effect of non-ionic contrast medium on renal function in children with cardiovascular disease. METHODS Analysis of renal function in 98 children with cardiovascular disease before and after the use of Iopamidol, Iohexol, and Ioversol was done for angiography. Serum creatinine (s-Cre), urinary N-acetyl-beta-D-glucosaminase (u-NAG),(More)
To assess the existence of endothelial dysfunction and the possibility of the early onset of atherosclerosis in the chronic stage of Kawasaki disease (KD), we examined endothelial function in adult patients late after the onset of KD. We evaluated two age-matched groups: 35 adult KD patients (KD group) (mean age, 27.0 years; mean interval time, 24.1 years),(More)
The existence of endothelial damage in impaired coronary arteries, both aneurysms and regressed aneurysms, even during the chronic stage of Kawasaki disease (KD) has been reported by morphologic and functional studies. In addition, based on our results of endothelial-dependent dilatation in systemic arteries or the pathological findings in weaning rabbits(More)
BACKGROUND Matrix metalloproteinases (MMPs) contribute to extracellular remodeling in Kawasaki disease (KD). MMP-9 is an essential vasculature-remodeling factor but its role in the vascular lesions of KD is not understood. This study focused on MMP-9 regulation via cytokines in endothelial cells (ECs). METHODS AND RESULTS Plasma and peripheral blood(More)
A single, 2 g/kg dose of immune globulin (IG), denoted 2 g-intravenous (IV)IG, has become a standard regimen for treating Kawasaki disease (KD) because of its highly preventive effect on coronary arterial lesions (CAL). However, IG is obtained from blood specimens, a drawback to many patients, and is also very expensive. This randomized prospective study(More)
BACKGROUND Conventional two-dimensional echocardiography (2DE) is not adequately sensitive enough for the detection of stenotic or occlusive coronary lesions that occur in Kawasaki disease. Recently, linear shadows have been detected inside large- or moderate-sized coronary artery lesions (CALs) by high-resolution 2DE at a convalescent or chronic stage. (More)
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