Ayumi Namimatsu

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Exposing mice to 24 and 4 degrees C in alternate 1 hr periods in the day time and maintaining 4 degrees C at night for several days decreases the tail clamp pressure required to evoke pain behavior. This model is referred to as SART (specific alternation rhythm of temperature) stress. An extract from inflamed skin of rabbits inoculated with vaccinia virus(More)
Increase in bone resorption by osteoclasts can cause metabolic bone diseases, such as osteoporosis. Recent attention has been paid to the receptor activator of the NF-kappaB ligand (RANKL), an accelerator of osteoclast differentiation. RANKL is expressed on the bone marrow-derived stromal cell membrane and induces the differentiation of osteoclasts by(More)
In order to investigate the function of the circulatory system in SART rats, systolic blood pressure and regional arterial blood flow were examined. It was found in SART stressed rats that the blood pressure was about 10 mmHg lower than that of the non-stressed group on the 6th day of stressing and after stressing, and such low blood pressure was maintained(More)
Electrocardiography (ECG) was performed for SART stressed (repeated cold stressed) mice which had changes in blood pressure and blood flow to examine the effects of this treatment on heart function. In the ECG of mice subjected to SART stress for 5 days, potentiations of the R and T voltage, a shortening of the PQ interval, a prolongation of the QRS(More)
In order to confirm the mechanism of nasal secretion mediated via a nerve reflex in guinea pigs, the secretory response from the contralateral side was studied which was induced by local application of various stimulators. There was no difference in the nasal secretion between the contralateral and the stimulated sides when the secretion was induced by(More)
In rats repeatedly cold-stressed by specific alternation of rhythm in environmental temperature (SART-stressed rats), the contractile response to acetylcholine (ACh) of the isolated duodenum was remarkably decreased, whereas the contractile responses to K+, Ba2+ and Ca2+ were comparable to those in non-stressed rats. The amount of [3H]quinuclidinyl(More)
To develop an animal model for experimental nasal hypersensitivity and hyperreactivity, guinea pigs were subjected to intermittent exposure to cold temperature (intermittent cold stress, SART stress) for 5 consecutive days. In SART-stressed guinea pigs, nasal mucosal hypersensitivity to histamine evoking sneeze response and nasal hypersecretion in response(More)
In guinea pigs actively sensitized with ovalbumin, we have observed that nasal hyperreactivity and hypersensitivity to methacholine causes nasal secretion accompanied by an increase in the density of muscarinic acetylcholine receptor (m-ACh.R) following the appearance of nasal symptoms induced by the ovalbumin challenge. Therefore in the present(More)
Anesthetized rats were perfused with saline in the subcutaneous space of the hind paw and the release of inflammatory mediators induced by noxious stimuli was studied. Not only immunoreactive bradykinin (BK) but also histamine, serotonin (5-HT) and immunoreactive prostaglandin E2 (PGE2) were found to be released into the perfusate when the paw was pinched.(More)
We stated that SART-stressed guinea pigs showing nasal mucosal hypersensitivity would serve as an animal model for the in vivo evaluation of antiallergic drugs. In the present study, the mode of action of Neurotropin on nasal allergy compared with those of antiallergic drugs was studied by using SART-stressed guinea pigs. Daily administrations of(More)