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Bidirectional Pharmacokinetic Interaction Between Amodiaquine and Pioglitazone in Healthy Subjects
Amodiaquine (AQ) and pioglitazone (PGZ) are both metabolized by CYP2C8, an enzyme also inhibited by PGZ. These drugs are likely to be administered in instances of comorbidity of malaria with type 2Expand
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Allele frequencies of thiopurine S-methyltransferase (TPMT) variants in the Nigerian population
Abstract Introduction Thiopurine S-methyltransferase (TPMT) methylates clinically relevant thiopurine drugs most of which are noted for adverse reactions in certain users, largely due toExpand
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Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population.
Polymorphisms in CYP2C8 and CYP3A5 genes have implications for responses elicited by the ingestion of some xenobiotics, the metabolism of which are mediated by these enzymes. CYP2C8*2, CYP2C8*3,Expand
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Simultaneous determination of amodiaquine and pioglitazone on dried blood spots (DBS) by HPLC–DAD and its usefulness in pharmacokinetic studies
ABSTRACT A simple and rapid method for simultaneous determination of amodiaquine and pioglitazone in dried blood spots (DBS) was developed and validated. Blood samples were spotted on protein saverExpand
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Relationship between metabolic phenotypes and genotypes of CYP1A2 and CYP2A6 in the Nigerian population
Abstract Background: CYP1A2 and CYP2A6 are polymorphic drug-metabolising enzymes that are also implicated in the activation of procarcinogens in humans. Some of their alleles and haplotypes, oftenExpand
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Thiopurine S-methyltransferase activity in Nigerians: phenotypes and activity reference values
ObjectivesThis study assessed the activity of thiopurine S-methyltransferase (TPMT) in Nigerians with a view to providing data on susceptibility to thiopurine toxicity, and as well generate referenceExpand
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Insight into clinically effective herbal antimalarial products: Effects on drug metabolizing enzymes and p-glycoprotein
Malaria is a leading cause of morbidity and mortality in many developing tropical countries, particularly in children and pregnant women. With growing concerns about the development of resistance toExpand
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In vitro metabolic stability and biotransformation of isosteviol in human and rat liver fractions.
Isosteviol is a lead compound whose cardioprotective property has been partly explained by its regulation of ion channels and interference with signalling pathways in the metabolism of some fattyExpand
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Pharmacokinetic Parameters of Quinine in Healthy Subjects and in Patients with Uncomplicated Malaria in Nigeria: Analysis of Data using a Population Approach
Highlights • Varied disposition imparts on the tolerance and safety of quinine, and thus constitutes a major limiting consideration for its dosing in uncomplicated malaria. Utilizing a populationExpand
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Pharmacogenomics in the Nigerian population: the past, the present and the future.
The Nigerian population exhibits huge ethnic and genetic diversity, typical of African populations, which can be harnessed for improved drug-response and disease management. Existing data on genesExpand