Aynur Aybey

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Human serum paraoxonase 1 (PON1; EC 3.1.8.1) is a high-density lipoprotein associated, calcium-dependent enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect the low-density lipoprotein against oxidation. In this study, in vitro inhibition effect of some dihydroxy coumarin compounds namely(More)
The role of quorum sensing (QS) in the regulation of virulence factor production in Pseudomonas aeruginosa is well established. Increased antibiotic resistance in this bacterium has led to the search for new treatment options, and inhibition of the QS system has been explored for potential therapeutic benefits. If the use of QS inhibitory agents were to(More)
Paraoxonase 1 (PON1) is human lactonase orginally described as enzyme that is capable of hydrolyzing organophosphates. The hypothesis suggested that this enzyme may also participate in attenuation of bacterial virulence through interfering with quorum sensing (QS). Recently, PON1 was shown to hydrolyze over 30 lactones. In the present study, human PON1(More)
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