Ayla Cihan Ozkan

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AIM OF STUDY Glioblastoma multiforme (GBM) is largely refractory to surgical operation, radiotherapy, and chemotherapy in use today. Remaining lifetime accounting for the GBM-affected patients varies between 12 and 16 months generally. The most frequently altered genes in GBM are p53, epidermal growth factor receptor, PTEN, and cyclin-dependent kinase(More)
An article published last year in the Journal of Medical Ethics compares giving birth at home to being as reckless as driving without putting a seatbelt on your child (de Crespigny and Savulescu 2014). Planning to give birth at home is often thought of as quite an 'alternative' decision, with just 2.4 per cent of women in England and Wales opting for this(More)
KRAS mutations are found in 15–25 % of patients with lung adenocarcinoma, and they lead to constitutive activation of KRAS signaling pathway that results in sustained cell proliferation. Currently, there are no direct anti-KRAS therapies available. Therefore, it is rational to target the downstream molecules of KRAS signaling pathway, which are(More)
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