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Several chemical modifications in the N(1)-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.
Complexity measures for sequences over finite fields, such as the linear complexity and the k-error linear complexity, play an important role in cryptology. Recent developments in stream ciphers point towards an interest in word-based stream ciphers, which require the study of the complexity of multisequences. We introduce various options for error linear… (More)
Recently the first author presented exact formulas for the number of 2 n-periodic binary sequences with given 1-error linear complexity, and an exact formula for the expected 1-error linear complexity and upper and lower bounds for the expected k-error linear complexity, k ≥ 2, of a random 2 n-periodic binary sequence. A crucial role for the analysis played… (More)
A standard model of nonlinear combiner generator for stream cipher system combines the outputs of several independent Linear Feedback Shift Register (LFSR) sequences using a nonlinear Boolean function to produce the key stream. Given such a model, cryptanalytic attacks have been proposed by finding out the sparse multiples of the connection polynomials… (More)
In our endeavor to design and synthesize novel anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for anticancer activity in vitro against a panel of human cancer cell lines. Most of these compounds exhibited cytotoxic activity in in vitro screens. Compounds were selected and further evaluated using a modified… (More)
A number of 5-aminosubstituted 20(S)-camptothecin analogues were prepared via semi-synthesis starting from 20(S)-camptothecin and 9-methoxy 20(S)-camptothecin. In vitro anti-cancer activity of these analogues was determined using 60 human tumor cell line assay. Although water solubility of most of these compounds was improved compared to 20(S)-camptothecin,… (More)
A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.
Azadirone 1, a limonoidal constituent of Azadirachta indica is found to possess potent cytotoxic activity against a panel of human cancer cell lines in our in vitro studies. In vitro screening of a number of semi-synthetic analogues of 1 revealed that the alpha,beta-unsaturated enone moiety or its equivalent conjugated system in A-ring, C-7… (More)