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A multicentered phase III clinical trial was conducted in seven countries to compare two dosages of depot-medroxyprogesterone acetate (DMPA), 100mg and 150mg, given every 90 days. Contraceptive efficacy and side-effects of both regimens were reported previously. Their effect on vaginal bleeding patterns is the object of this paper. A total of 1216 women(More)
OBJECTIVE To determine the efficacy of the lactational amenorrhea method of family planning (amenorrhea during full or nearly full breastfeeding for 6 months postpartum). DESIGN Prospective noncomparative study. SETTING Normal breastfeeding women in Karachi and Multan, Pakistan, most delivered at home by a midwife. PATIENTS Three hundred ninety-nine(More)
It is unknown whether a user's understanding of the Lactational Amenorrhea Method (LAM) is related to its successful use. A study of 876 LAM users in Pakistan and the Philippines collected information about women's understanding of LAM. The present analysis aims to determine: (1) the proportion of LAM users who understand the method, (2) whether any known(More)
Two dosages of depot-medroxyprogesterone acetate (DMPA), 100 mg and 150 mg given every 90 days, were compared in two groups of women with regard to effectiveness, reported complaints and reasons for discontinuation. A total of 1216 women were recruited into a seven-centre, multinational, randomized clinical trial. Follow-up was for a period of one year and(More)
A longitudinal driving simulator study was completed in order to examine drivers’ level of trust and the type of conceptual model they held of an Adaptive-Cruise-Control system (ACC). Fifteen drivers participated in a ten day study where they were allocated to one of three ACC conditions. This was either a reliable ACC condition (100%), semireliable ACC(More)
A placebo-controlled randomized clinical trial was conducted in six centres to compare the effects of a 14 day treatment with either 50 micrograms ethinyl oestradiol daily or 2.5 mg oestrone sulphate daily, on depot medroxyprogesterone acetate (DMPA)-induced prolonged bleeding. Out of 1035 women admitted to the study, 278 requested treatment and were given(More)
A longitudinal study of breastfeeding women was conducted to determine whether breastfeeding frequency is associated with the length of postpartum amenorrhea. The data are also conducive to testing the guidelines of the "Bellagio Consensus" (i.e., that there is no more than a 2% chance of pregnancy during breastfeeding in the first six months postpartum in(More)
Three hundred and sixty five volunteers were observed for a total of 4882 woman-months for the clinical evaluation of MLCu375. Data were analyzed by life-table method at 6, 12 and 18 months. Most women were 21-30 years old, and of parity 2-4. Continuation rates of 78.2 and 68.8 at 12 and 18 months, respectively, and a pregnancy rate of 0.3% proved the(More)
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