Ayano Kowata

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Protein phosphatase magnesium-dependent 1δ (PPM1D, Wip1) is a p53 inducible serine/threonine phosphatase. PPM1D is a promising target protein in cancer therapy since overexpression, missense mutations, truncating mutations, and gene amplification of PPM1D are reported in many tumors, including breast cancer and neuroblastoma. Herein, we report that a(More)
We developed a new method for stereoselective construction of an all-carbon quaternary stereogenic center on a carbocyclic ring based on regio- and stereoselective S(N)2' alkylation reactions of γ,δ-epoxy-α,β-unsaturated cyclic ketones. Treatment of the ketones, which were readily prepared in enantiomerically pure form by means of aldol condensations(More)
Title Stereocontrolled synthesis of carbocyclic compounds with a quaternary carbon atom based on SN2 ' alkylation of γ,δ-epoxy-α,β-unsaturated ketones Author(s) Yoshimura, Fumihiko; Kowata, Ayano; Tanino, Keiji Citation Organic & Biomolecular Chemistry, 10(28): 5431-5442 Issue Date 2012-07-28 Doc URL http://hdl.handle.net/2115/52793 Right Org. Biomol.(More)
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