Ayako Meguro

Learn More
Mesenchymal stromal cells (MSCs) have been shown to have an immunosuppressive effect. Previously, we demonstrated that nitric oxide (NO) is one of the immunomodulatory mediators of MSCs. We herein show that primary mouse bone marrow MSCs and three cell lines that mimic MSCs suppress both differentiation and proliferation in Th1 condition, whereas the(More)
Immunological effects of IL-21 on T, B and natural killer (NK) cells have been reported, but the role of IL-21 in GVHD remains obscure. Here, we demonstrate that morbidity and mortality of GVHD was significantly reduced after BMT with splenocytes from IL-21R−/− mice compared with those from wild type mice. To further confirm our observation, we generated a(More)
BACKGROUND The molecular mechanisms underlying the biologic effects or differentiation of mesenchymal stromal cells (MSC) have not been clarified. Screening for genes differentially expressed at different stages is an important step in determining these molecular mechanisms. METHODS In this study, we analyzed the gene expression profiles of C3H10T1/2(More)
Previously, we have shown that IL-21R−/− splenocytes ameliorate GVHD as compared with wild-type splenocytes. Here, we investigated whether or not IL-21R−/− splenocytes diminish the graft-versus-leukemia (GVL) effect. Surprisingly, IL-21R−/− splenocytes efficiently eliminate leukemic cells as well as wild-type splenocytes, suggesting the retention of GVL(More)
Human normal, periodontitis and overgrown gingival fibroblasts were assayed concerning proinflammatory cytokines secreting ability. Stimulating effect of gingival overgrowth-inducing drugs such as phenytoin, nifedipine or cyclosporine A and LPS on the secretion ability of each fibroblast specimen was also estimated. The supernatant of cultured medium was(More)
1473-0502/$ see front matter 2013 Elsevier Ltd. All rights r http://dx.doi.org/10.1016/j.transci.2013.02.045 To the editor, Recently, the Japanese Marrow Donor Program (JMDP) reported that 3 patients with transplanted hemolyzed bone marrow (BM) showed severe adverse effects related to hemolysis [1]. In these cases, each BM was collected in a hospital and(More)
  • 1