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Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage
TLDR
Genetic deletion of sEH reduces vascular inflammation and edema and improves outcome after subarachnoid hemorrhage and may serve as a novel therapy for SAH. Expand
Circadian disruption of food availability significantly reduces reproductive success in mice
TLDR
It is concluded that mistimed feeding inhibits reproduction in mice by reducing successful mating behavior and is relevant to understanding impaired fertility in shift workers. Expand
Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment
TLDR
It is demonstrated that the UCCAO model of chronic hypoperfusion induces hippocampal atrophy and ventricular enlargement, resulting in neurocognitive deficits characteristic of VCI. Expand
High-dose estrogen treatment at reperfusion reduces lesion volume and accelerates recovery of sensorimotor function after experimental ischemic stroke
TLDR
E2 treatment administered immediately following reperfusion significantly reduced lesion size, cyst formation, and brain atrophy while improving lesional CBF and accelerating recovery of functional deficits in a rat model of ischemic stroke. Expand
Synergistic Antivascular and Antitumor Efficacy with Combined Cediranib and SC6889 in Intracranial Mouse Glioma
TLDR
The study represents the first demonstration that the combination of cediranib with a proteasome inhibitor substantially increases the anti-angiogenic efficacy produced from either agent alone, and synergistically slows glioma tumor growth and extends survival, suggesting a promising treatment which warrants further investigation. Expand
Natural food intake patterns have little synchronizing effect on peripheral circadian clocks
TLDR
These data suggest that natural feeding patterns can only weakly affect circadian clocks, and that in normally feeding mice, the central pacemaker in the brain may set the phase of peripheral organs via pathways that are independent of feeding behavior. Expand
Rapid Response and Slow Recovery of the H3K4me3 Epigenomic Marker in the Liver after Light-mediated Phase Advances of the Circadian Clock
TLDR
Both a rapid response to the phase advance and a delayed recovery are found, the latter in sync with H3K4me3 levels, which are found at active and poised gene promoters in the liver epigenome. Expand
Natural food intake patterns do not synchronize peripheral clocks
TLDR
Food is thought to synchronize circadian clocks in the body, but this is based on time-restricted feeding (TRF) protocols, and under natural feeding patterns, the master pacemaker in the brain sets the phase of peripheral organs independent of feeding behavior. Expand