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Controlled production of stable heterologous proteins in Lactococcus lactis.

• Aya Miyoshi, Isabelle Poquet, +6 authors Philippe Langella
• Applied and environmental microbiology
• 2002

The use of Lactococcus lactis (the most extensively characterized lactic acid bacterium) as a delivery organism for heterologous proteins is, in some cases, limited by low production levels and… (More)

Multiplex amplified product-length polymorphism analysis of 36 mitochondrial single-nucleotide polymorphisms for haplogrouping of East Asian populations.

• Kazuo Umetsu, Masashi Tanaka, +7 authors Motoki Osawa
• Electrophoresis
• 2005

We present a reliable, rapid, and economical multiplex amplified product-length polymorphism (APLP) method for analyzing the haplogroup-diagnostic mitochondrial single-nucleotide polymorphisms… (More)

Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation.

• Yasuko Ishii, Aya Miyoshi, +8 authors Kazuta Oguri
• Molecular pharmacology
• 2001

Although UDP-glucuronosyltransferases (UGTs) act as an important detoxification system for many endogenous and exogenous compounds, they are also involved in the metabolic activation of morphine to… (More)

Ligand-activated PPARβ efficiently represses the induction of LXR-dependent promoter activity through competition with RXR

• Kimihiko Matsusue, Aya Miyoshi, Shigeru Yamano, Frank J. Gonzalez
• Molecular and Cellular Endocrinology
• 2006

Angiopoietin-like protein 3 (angptl3), a member of the vascular endothelial growth factor family, was shown to play an important role in regulating lipid metabolism. To elucidate the mechanism by… (More)

Distribution of the F374 allele of the SLC45A2 (MATP) gene and founder-haplotype analysis.

• Isao Yuasa, Kazuo Umetsu, +9 authors Jürgen Henke
• Annals of human genetics
• 2006

The membrane-associated transporter protein (MATP) plays an important role in melanin synthesis. The L374F mutation in the SLC45A2 gene encoding MATP has been suggested to be associated with skin… (More)

Multiplex amplified product-length polymorphism analysis for rapid detection of human mitochondrial DNA variations.

• Kazuo Umetsu, Masashi Tanaka, +10 authors Motoki Osawa
• Electrophoresis
• 2001

A number of mutations in coding and noncoding regions of mitochondrial DNA (mtDNA) have previously been studied. In the present study, we simultaneously typed six mutation sites in the coding region… (More)

Allele frequencies of a SNP and a 27-bp deletion that are the determinant of earwax type in the ABCC11 gene.

• Takashi Kitano, Isao Yuasa, +4 authors Kazuo Umetsu
• Legal medicine
• 2008

Allele frequencies for a SNP (rs17822931) and a 27-bp deletion that are the determinant of earwax type in the ABCC11 gene were investigated in seven Japanese, one Korean, and one German populations.… (More)

Two simple methods for enantiomeric analyses of urinary amphetamines by GC/MS using deuterium-labeled l-amphetamines as internal standards

• Zhao Fang Liu, Kenji Hara, +6 authors Mitsuyoshi Kageura
• Forensic Toxicology
• 2006

Two simple methods for enantiomeric analyses of amphetamines in urine by gas chromatography-mass spectrometry (GC-MS) using l-amphetamine-d 3 and l-methamphetamine-d 6 as internal standards are… (More)

Efficacy and safety of apixaban in the patients undergoing the ablation of atrial fibrillation.

• Tomoyuki Nagao, Yasuya Inden, +11 authors Toyoaki Murohara
• Pacing and clinical electrophysiology : PACE
• 2015

INTRODUCTION Apixaban, a factor Xa (FXa) inhibitor, is a new oral anticoagulant for stroke prevention in atrial fibrillation (AF). However, little is known about its efficacy and safety as a… (More)

Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation.

• Yuji Ishii, Aya Miyoshi, D. Maji, Hideyuki Yamada, Kazuta Oguri
• Drug metabolism and disposition: the biological…
• 2004

Our previous study suggested that hetero-oligomer formation of guinea pig liver UDP-glucuronosyltransferases (UGTs) 2B21 and 2B22 enhances UGT2B21-catalyzed morphine-6-glucuronidation. In this work,… (More)

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