Aya Abdalla

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It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional recovery after injury. Studies using fixed tissue have suggested that serotonin neurons might be a notable exception, but remain inconclusive. We have employed in vivo two-photon microscopy to produce time-lapse images of(More)
Histamine and serotonin are neuromodulators which facilitate numerous, diverse neurological functions. Being co-localized in many brain regions, these two neurotransmitters are thought to modulate one another's chemistry and are often implicated in the etiology of disease. Thus, it is desirable to interpret the in vivo chemistry underlying neurotransmission(More)
Research Areas: Real-time Quantitative Neurotransmitter Measurements: We are developing cutting-edge electrochemical technology to monitor the brain's molecules in real time. Of particular interest to us are the neurotransmitters serotonin and histamine. Serotonin and histamine dysfunction are thought to underlie a variety of diseases including mood and(More)
Histamine plays a major role in the mediation of allergic reactions such as peripheral inflammation. This classical monoamine is also a neurotransmitter involved in the central nervous system but its role in this context is poorly understood. Studying histamine neurotransmission is important due to its implications in many neurological disorders. The(More)
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