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INTRODUCTION Strenuous exercise induces significant increases in cardiac biomarkers. However, it is still unclear whether this is caused by cardiomyocyte necrosis or secondary mechanisms such as ischemia, cardiac energy deficiency, increased inflammation, or renal dysfunction. METHODS Therefore, we investigated cardiac biomarkers (high-sensitive cardiac(More)
BACKGROUND Interventions aimed at behavior change are increasingly being delivered over the Internet. Although research on intervention effectiveness has been widely conducted, their true public health impact as indicated by reach, effectiveness, and use is unclear. OBJECTIVE The aim of this paper is to (1) review the current literature on online(More)
Coronary artery disease is the leading cause of death worldwide. A sedentary lifestyle accounts for 9% of premature mortality and creates a substantial health economic burden. Measurement of physical activity in daily practice refers to metabolic equivalent tasks and assessment of cardiopulmonary fitness to measurements of peak oxygen uptake during(More)
Borg’s rating of perceived exertion (RPE) is a widely used psycho-physical tool to assess subjective perception of effort during exercise. We evaluated the association between Borg’s RPE and physiological exercise parameters in a very large population. In this cohort study, 2,560 Caucasian men and women [median age 28 (IQR 17–44) years] completed(More)
OBJECTIVE To evaluate the effect of structured vs. non-structured internet-delivered exercise recommendations on aerobic exercise capacity and cardiovascular risk profile in overweight sedentary employees. METHODS 140 employees of an automobile company (11% female, median age 48 years (range 25-60), BMI 29.0 kg/m(2) (25.0-34.8)) were randomized in a 3:2(More)
BACKGROUND The retinal microcirculation is affected early in the process of atherosclerosis and retinal vessel caliber is an emerging cardiovascular risk factor. Obesity is associated with vascular dysfunction. Here, we investigate the effect of regular exercise on retinal vessel diameters in lean and obese runners. We analyze a possible link to alterations(More)
Patients after coarctation repair still have an increased risk of cardiovascular or cerebrovascular events. This has been explained by the persisting hypertension and alterations in the peripheral vessels. However, involvement of the central vessels such as the retinal arteries is virtually unknown. A total of 34 patients after coarctation repair (22 men(More)
PURPOSE Strenuous exercise induces significant increases in inflammatory and cardiac biomarkers and transient dysfunction of the left ventricle. It is still unclear whether the electrophysiological correlate of these alterations can also be observed in ECG recordings, which indicate increased vulnerability for arrhythmias. METHODS ECG parameters were(More)
The influence of regular exercise on cardiac remodeling after aortic valve replacement (AVR) is virtually unknown. The case is reported of a 49-year-old male patient who had undergone biological valve replacement for severe aortic regurgitation with reduced left ventricular ejection fraction (LVEF; 45%) and massive left ventricular dilation (left(More)
OBJECTIVE Previous studies indicate an association between marathon running and premature atherosclerosis. Retinal vessel diameter alterations, in particular narrower arterioles and wider venules, reflect early stages of atherosclerosis, but the influence of marathon on the retinal microcirculation is unknown. METHODS Retinal vessel diameters were(More)