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Recent data indicate that TGFbeta3, one member of the TGFbeta-isoforms, has an important role in bone remodeling. Up to date little is known about the expression and regulation of TGFbeta3 in man. We established a highly specific ELISA for quantitative measurement of TGFbeta3 in bone and blood samples and a RT-PCR in combination with HPLC for detection and(More)
The authors report on a prospective multicenter study with regard to the operative treatment of acute fractures and dislocations of the thoracolumbar spine (T10-L2). The study should analyze the operative methods currently used and determine the results in a large representative collective. This investigation was realized by the working group "spine" of the(More)
Transforming growth factor beta is one of the most abundant growth factors stored in bone. It is known as a potent regulator of osteoblast proliferation and differentiation as well as of production extracellular matrix. We established a highly specific RT-PCR in combination with HPLC for detection and quantification of TGFbeta1 and TGFbeta2 mRNA expression(More)
Cylindric titanium rods with different surfaces were axially implanted into the femora of sheep. The three surfaces were grit-blasted titanium, plasma-sprayed titanium and plasma-sprayed hydroxyapatite (HA). After 2 months, a 2-cm segment of the femoral shaft was completely resected to load the implant, and the animals were allowed full weight-bearing for 9(More)
The authors report on a prospective multicenter study with regard to the operative treatment of fractures and dislocations of the thoracolumbar spine. 18 traumatologic centers in Germany and Austria, forming the working group "spine" of the German Society of Trauma Surgery, are participating in this continuing study. Between September 1994 and December 1996(More)
BACKGROUND Complications of external fixation include loosening of the fixation pins and pin-track infection. Laboratory studies and clinical trials have suggested that hydroxyapatite coating improves the osteointegration of various orthopaedic implants. The purpose of this study was to determine whether the prevalence of pin-related complications can be(More)
Arthrodesis of the ankle joint is commonly, performed to treat severe arthritis. Three different techniques have been biomechanically evaluated for initial stability: fusion with three isolated tibio-talar lag screws (type I), which was inaugurated by Wagner; a second fusion technique with two isolated tibio-talar lag screws and an anterior tibio-talar(More)
Trochanteric fractures frequently occur in elder patients with severe osteopenia. These fractures are highly unstable. Conservative treatment is not indicated because of the long period of immobilization until fracture healing is achieved. Simple fractures (A1) can be successfully fixed by either plate-hip screw systems like Dynamic Hip Screw (DHS) or(More)
We analyzed the failure of Schanz pins in 234 patients with fractures of the lower extremity. All patients had the AO external fixator and stainless steel pins (ISO 58/32-1). The mean duration of treatment was 14 weeks. During this time 88 of a total of 1147 pins became loose. The first failures occurred 2 weeks after insertion. Most pins failed after 5-6(More)
The removal torque and the loosening and infection rates of AO/ASIF 4.5 mm Schanz screws (MS) have been compared with those of hydroxyapatite-coated (HA) and hydroxyapatite/silver phosphate-coated (HA/P) AO/ASIF Schanz screws in vivo. In sheep, the left tibia was fixed after a midshaft osteotomy by means of unilateral fixator with 6 Schanz screws in an(More)