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Telomerase-negative immortalized human cells maintain their telomeres by a mechanism known as alternative lengthening of telomeres (ALT). We report here that ALT cells contain a novel promyelocytic leukemia (PML) body (ALT-associated PML body, APB). APBs are large donut-shaped nuclear structures containing PML protein, telomeric DNA, and the telomere(More)
Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative cell divisions. DDR+ telomeres at replicative senescence retain TRF2 and RAP1 proteins, are not associated with end-to-end fusions and(More)
Community networks are an emerging and successful model for the Future Internet across Europe and far beyond. The CONFINE project complements existing FIRE (Future Internet Research and Experimentation) infrastructures by establishing Community-Lab, a new facility for experimentally-driven research built on the federation of existing community IP networks(More)
Nowadays there are inexpensive WiFi devices that have fostered the deployment of wireless communities. Well known routing protocols used in the Internet do not fit well to time varying characteristic of wireless networks. This has motivated an intensive research on routing protocols for wireless mesh networks. At this time there are a number of mature and(More)
The linear chromosomes of vertebrates terminate in telomeres that consist of a tandemly repeated hexameric sequence, 5'TTAGGG3'. Telomeres form a protective loop structure (t-loop), which is thought to prevent them from being recognized as a double-strand break. Approximately 10% of human tumors prevent shortening of their telomeres by using a(More)
Telomeres in cells that use the recombination-mediated alternative lengthening of telomeres (ALT) pathway elicit a DNA damage response that is partly independent of telomere length. We therefore investigated whether ALT telomeres contain structural abnormalities that contribute to ALT activity. Here we used next generation sequencing to analyze the DNA(More)
Telomere lengths are maintained in many cancer cells by the ribonucleoprotein enzyme telomerase but can be further elongated by increasing telomerase activity through the overexpression of telomerase components. We report here that increased telomerase activity results in increased telomere length that eventually reaches a plateau, accompanied by the(More)
Community Networks are large scale, self-organized and decentralized networks, built and operated by citizens for citizens. In this paper, we make a case for research on and with community networks, while explaining the relation to Community-Lab. The latter is an open, distributed infrastructure for researchers to experiment with community networks. The(More)
Alternative lengthening of telomeres (ALT) is a telomere length maintenance mechanism based on recombination, where telomeres use other telomeric DNA as a template for DNA synthesis. About 10% of all human tumors depend on ALT for their continued growth, and understanding its molecular details is critically important for the development of cancer treatments(More)
Nowadays, a growing number of communities of citizens build, operate and own open IP-based community wireless networks with thousands of low capacity nodes actively participating in routing the data traffic. This article focuses on one of their concerns, routing and its scalability, by presenting BatMan-eXperimental Version 6 (BMX6) and evaluating its(More)