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Differences in the risk of celiac disease associated with HLA-DQ2.5 or HLA-DQ2.2 are related to sustained gluten antigen presentation
TLDR
The findings suggest that the kinetic stability of complexes of peptide and major histocompatibility complex (MHC) is of importance for the association of HLA with disease. Expand
Spatiotemporal Resolution of Rab9 and CI‐MPR Dynamics in the Endocytic Pathway
TLDR
It is demonstrated that Rab9 mediates the delivery of CI‐MPR to the endosomal pathway, entering the maturing endosome at the early‐to‐late transition. Expand
Differential regulation of MHC II and invariant chain expression during maturation of monocyte‐derived dendritic cells
TLDR
It is found that the production of Ii did not correlate with that of MHC II and that mature DCs maintain abundant levels of I i despite a reduced production of new MHCII. Expand
The human‐specific invariant chain isoform Iip35 modulates Iip33 trafficking and function
The invariant chain (Ii) is a multifunctional protein, which has an essential role in the assembly and transport of major histocompatibility complex class II (MHC II) molecules. From a single gene,Expand
Differential Regulation of Rab GTPase Expression in Monocyte-Derived Dendritic Cells upon Lipopolysaccharide Activation: A Correlation to Maturation-Dependent Functional Properties
TLDR
The regulation of Rab expression to modulate cellular function has recently been proposed and it is found that Rab expression is altered upon lipopolysaccharide-induced activation, and this correlates to the reported functions of these cells during maturation. Expand
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
TLDR
A dose-dependent addiction to IL-15 is described during in vitro expansion of human NK cells, leading to caspase-3 activation and profound cell death upon IL- 15 withdrawal, shed new light on the molecular mechanisms involved in NK cell apoptosis following cytokine withdrawal and may guide future NK cell priming strategies in a cell therapy setting. Expand
Polymorphic residues of HLA-DQ2.2 and HLA-DQ2.5 that affect CLIP presentation and stability
TLDR
Findings presented in this thesis show that the polymorphisms in positions α31, α37 and α72 also have an effect on CLIP presentation and stability in HLA-DQ2.5 and HLA2.2, and may help explain some of the results presented there. Expand