This paper reviews the role of the central nervous system in the genesis of gastrointestinal mucosal injuries. The discussion makes particular reference to the significance and mechanism of stress-induced injury of the gastroduodenal mucosa. It points out that in the rat, stress activates the hypothalamus, producing delivery of alpha-adrenergic stimulation… (More)
Distension of the gallbladder and bacterial infection can perpetuate an attack of acute calculous cholecystitis and produce its local and systemic complications. This prospective randomized trial was conducted on patients with their first episode of acute calculous cholecystitis which was associated with pyrexia and tachycardia to examine whether ultrasound… (More)
In the rat, stress activates the hypothalamus inducing central sympathetic discharge and delivery of alpha-adrenergic stimulation to the stomach by the adrenergic hypothalamovagal pathway. This stimulation controls intragastric blood flow and 5-HT release. Administration of reserpine produces stress pharmacologically and stimulates the mentioned pathway.… (More)
This review describes some of the mechanisms which are thought to be important in the causation of pain in chronic pancreatitis. Both medical and surgical techniques for treating this pain are described.
Administration of 98% ethanol destroys tissues by coagulative necrosis. In the rat bearing 1,2-dimethylhydrazine-induced colonic carcinoma which has spread to the liver, direct injection of 0.1-0.2 ml ethanol into each of the hepatic metastases at the time of total colectomy afforded a significant survival advantage relative to colectomy alone (20.1 +/- 0.2… (More)
The quality of immediate repair of common bile duct injuries with or without tissue loss occurring during elective cholecystectomy is crucial and maybe the sole factor behind future stricture formation with its considerable morbidity and mortality. Successful repair of iatrogenic common bile duct injuries has been achieved by immediate saphenous vein grafts… (More)
Further to my recent publication in the Journal on the percutaneous management of acute calculous cholecystitis1, I would like to communicate the results of a prospective randomized study conducted at the Medical City in Baghdad, Iraq to examine the role of percutaneous aspiration of the gallbladder followed by lavage and antibiotic instillation into its… (More)
The abdominal pain produced by chronic pancreatitis may be very difficult to treat. Oxygen-derived free radicals, such as the superoxide anion and hydroxyl radical, are cytotoxic and promote tissue damage1'2. These radicals injure cellular membranes and release the intracellular components, e.g. lysosomal enzymes, that can lead to further tissue damage3'4.… (More)