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The role of low affinity, heparin-like binding sites for basic fibroblast growth factor (bFGF) was investigated in CHO cells mutant in their metabolism of glycosaminoglycans. Heparan… (More)
- Joseph E. Schlessinger, Alexander N. Plotnikov, +5 authors Moosa Mohammadi
- Molecular cell
- 2000
The crystal structure of a dimeric 2:2:2 FGF:FGFR:heparin ternary complex at 3 A resolution has been determined. Within each 1:1 FGF:FGFR complex, heparin makes numerous contacts with both FGF and… (More)
- David M Ornitz, Avner Yayon, John G. Flanagan, Carl M. Svahn, Ester Levi, Philip Leder
- Molecular and cellular biology
- 1992
Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan. So that this heparin… (More)
- Avi Orr-Urtreger, Mark T Bedford, +5 authors Peter Lonai
- Developmental biology
- 1993
The gene for fibroblast growth factor receptor-2 (FGFR2) encodes two splice variants designated here as keratinocyte growth factor (KGFR) and bek. Their ligand-binding specificity is markedly… (More)
- Lin Chen, Rivka Adar, +5 authors Chu-Xia Deng
- The Journal of clinical investigation
- 1999
Missense mutations in fibroblast growth factor receptor 3 (FGFR3) result in several human skeletal dysplasias, including the most common form of dwarfism, achondroplasia. Here we show that a… (More)
A survey of defined species of cell surface and extracellular matrix heparan sulfate proteoglycans (HSPG) was performed in a search for cellular proteoglycans that can promote bFGF receptor binding… (More)
- Avi Orr-Urtreger, David Givol, Avner Yayon, Yosef Yarden, Peter Lonai
- Development
- 1991
Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were… (More)
- Dale Allen Fortin, Eran Rom, Haijun Sun, Avner Yayon, Rashmi Bansal
- The Journal of neuroscience : the official…
- 2005
Fibroblast growth factors (FGFs) have been implicated in numerous cellular processes, including proliferation, migration, differentiation, and survival. Whereas FGF-2, the prototypic ligand in a… (More)
- Ester Levi, Rafael Fridman, Hua Quan Miao, Yanhan Ma, Avner Yayon, Israel Vlodavsky
- Proceedings of the National Academy of Sciences…
- 1996
Recent studies have demonstrated the existence of a soluble fibroblast growth factor (FGF) receptor type 1 (FGFR1) extracellular domain in the circulation and in vascular basement membranes. However,… (More)
- David Givol, Avner Yayon
- FASEB journal : official publication of the…
- 1992
Since 1989, the receptors for fibroblast growth factors (FGFs) were cloned and characterized as a subgroup of the family of receptor tyrosine kinases. Four FGF receptor genes were identified, all of… (More)