Avinoam Ben-Shaul

Yifat Brill-Karniely2
Yaron Ideses2
2Yifat Brill-Karniely
2Yaron Ideses
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Membrane-bound receptors often form large assemblies resulting from binding to soluble ligands, cell-surface molecules on other cells, and extracellular matrix proteins 1. For example, the association of membrane proteins with proteins on different cells (trans interactions) can drive the oligomerization of proteins on the same cell (cis interactions) 2. A(More)
During cellular migration, regulated actin assembly takes place at the cell leading edge, with continuous disassembly deeper in the cell interior. Actin polymerization at the plasma membrane results in the extension of cellular protrusions in the form of lamellipodia and filopodia. To understand how cells regulate the transformation of lamellipodia into(More)
We show on general theoretical grounds that the two ends of single-stranded (ss) RNA molecules (consisting of roughly equal proportions of A, C, G and U) are necessarily close together, largely independent of their length and sequence. This is demonstrated to be a direct consequence of two generic properties of the equilibrium secondary structures, namely(More)
We present a simple statistical thermodynamic model for budding of viral nucleocapsids at the cell membrane. The membrane is modeled as a flexible lipid bilayer embedding linker (spike) proteins, which serve to anchor and thus wrap the membrane around the viral capsids. The free energy of a single bud is expressed as a sum of the bending energy of its(More)
We describe a new approach to calculate the binding of flexible peptides and unfolded proteins to multicomponent lipid membranes. The method is based on the transfer matrix formalism of statistical mechanics recently described as a systematic tool to study DNA-protein-drug binding in gene regulation. Using the energies of interaction of the individual(More)
Cross-linking proteins can mediate the emergence of rigid bundles from a dense branched network of actin filaments. To enable their binding, the filaments must first bend towards each other. We derive an explicit criterion for the onset of bundling, in terms of the initial length of filaments L, their spacing b, and cross-linker concentration f, reflecting(More)
Macroion adsorption on a mixed, fluid, lipid membrane containing oppositely charged lipids induces local changes in lipid composition at the interaction zones, and gradients at their boundaries. Including these effects in the free energy of the macroion-dressed membrane we derive its spinodal equation, and show that nonideal lipid mixing can lead to(More)
A majority of viruses are composed of long single-stranded genomic RNA molecules encapsulated by protein shells with diameters of just a few tens of nanometers. We examine the extent to which these viral RNAs have evolved to be physically compact molecules to facilitate encapsulation. Measurements of equal-length viral, non-viral, coding and non-coding RNAs(More)
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