Avinash Balakrishnan

Learn More
The aim of the present study is to probe the anti-inflammatory potential of the plant Boswellia serrata by studying the effect of the crude extract and the pure compound isolated from it on key inflammatory mediators like TNFalpha, IL-1beta, and NO thus enabling the understanding of the key signaling events involved. The crude methanolic extract and the(More)
Conventional solvent fractionation and bioactivity based target assays were used to identify a new anti-cancer molecule from Phyllanthus urinaria, a herbal medicinal plant used in South India. At each step of the purification process the different fractions that were isolated were tested for specific anti-proliferative activity by assays measuring the(More)
We report on the development and characterization of high performance supercapacitor electrodes synthesized using electrophoretic deposition of graphene, upon which the poly(pyrrole)-layer was electropolymerised. The highly capacitive electrode had a specific capacitance of 1510 F g(-1), area capacitance of 151 mF cm(-2) and volume capacitance of 151 F(More)
The anti-inflammatory effect of the medicinal plant, Commiphora mukul gum was studied in peripheral blood mononuclear cells (PBMC). Bioassay-guided fractionation using conventional solvent extraction procedures, subsequent column fractionation, followed by monitoring specific activity in PBMC led to the isolation of a lead compound. Both crude ethyl acetate(More)
AIMS To establish the role of maltoporin (LamB) in adherence of enteropathogenic Escherichia coli (EPEC) to epithelial cells in vitro. METHODS AND RESULTS Three strains, wild type (WT) EPEC, a maltoporin (LamB) mutant DeltalamB, and DH5alpha were used to study adherence to cultured HEp-2 cells. Mutant DeltalamB was found to be deficient in adherence(More)
The present study demonstrates an original approach by which Au nanoparticles (approximately 10 nm) are embedded into TiO2 fibers via electrospinning. The photocatalytic performance of the resultant fibrous material was studied and related to the architecture and the nature of the internal interfaces in the composite. It was found that embedment of nano Au(More)
The present study is on the growth inhibitory effect of Withania somnifera methanolic leaf extract and its active component, withanolide on HL-60 promyelocytic leukemia cells. The decrease in survival rate of HL-60 cells was noted to be associated with a time dependent decrease in the Bcl-2/Bax ratio, leading to up regulation of Bax. Both the crude leaf(More)
In this paper, we have synthesized electrospun TiO2 nanofibers embedded with bimodal sized and prismatic gold nanoparticles. The surface plasmons generated in the gold nanoparticles were used to enhance the performance of photocatalysis. The photocatalytic conversion efficiencies of these bimodal sized/prismatic gold nanoparticles when embedded in(More)
The purpose of the present study is to investigate the effect of methanolic extracts of Aegles marmelos and Syzygium cumini on a battery of targets glucose transporter (Glut-4), peroxisome proliferator activator receptor gamma (PPARgamma) and phosphatidylinositol 3' kinase (PI3 kinase) involved in glucose transport. A. marmelos and S. cumini are(More)
In this study, we report the synthesis of a novel Mannich base, salicylideneacetanato methyl dimethylamine (SAMDM), and its transition metal complexes.Salicylideneacetone , a condensation product from salicylaladehyde was used as a precursor and treated with formaldehyde and dimethylamine. The so formed base is complexed with transition metals. The progress(More)