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Berberine and S allyl cysteine mediated amelioration of DEN+CCl4 induced hepatocarcinoma.

• Dipanwita Sengupta, Kaustav Dutta Chowdhury, Avik Sarkar, Soumosish Paul, Gobinda Chandra Sadhukhan
• Biochimica et biophysica acta
• 2014

BACKGROUND Diethylnitrosamine (DEN) and carbon tetrachloride (CCl4) have been used as initiator and promoter respectively to establish an animal model for investigating molecular events appear to be… (More)

S-allyl cysteine in combination with clotrimazole downregulates Fas induced apoptotic events in erythrocytes of mice exposed to lead.

• Samir K Mandal, Sudip Mukherjee, +8 authors Gargi Sen
• Biochimica et biophysica acta
• 2012

BACKGROUND Chronic lead (Pb(2+)) exposure leads to the reduced lifespan of erythrocytes. Oxidative stress and K(+) loss accelerate Fas translocation into lipid raft microdomains inducing Fas mediated… (More)

Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats.

• D. C. Biswas, Gargi Sen, Avik Sarkar, Tuli Biswas
• Toxicology and applied pharmacology
• 2011

Arsenic is an environmental toxicant that reduces the lifespan of circulating erythrocytes during chronic exposure. Our previous studies had indicated involvement of hypercholesterolemia and reactive… (More)

Role of endothelial dysfunction in modulating the plasma redox homeostasis in visceral leishmaniasis.

• Kaustav Dutta Chowdhury, Gargi Sen, Avik Sarkar, Tuli Biswas
• Biochimica et biophysica acta
• 2011

BACKGROUND Evidence in the literature suggests that down-regulation of nitric oxide (NO) is associated with the pathophysiological conditions during visceral leishmaniasis (VL). Here we have… (More)

SAC and Berberine Mediated Repression of Reactive Species and Hepatoprotection After DEN + CCl4 Exposure

• Dipanwita Sengupta, Sujan Chatterjee, +7 authors Gobinda Chandra Sadhukhan
• Proceedings of the Zoological Society
• 2015

Oxidative stress is proposed to play a pivotal role in the development of hepatocellular carcinoma. With an accelerated metabolism cancer cells demand high reactive species accumulation to maintain… (More)

Free radical stress induces DNA damage response in RAW264.7 macrophages during Mycobacterium smegmatis infection

• Chinmoy Ghosh, Avik Sarkar, +7 authors Surajit Bhattacharjee
• Archives of Microbiology
• 2018

Genomic instability resulting from oxidative stress responses may be traced to chromosomal aberration. Oxidative stress suggests an imbalance between the systemic manifestation of reactive free… (More)

Modulation of adenylate cyclase signaling in association with MKK3/6 stabilization under combination of SAC and berberine to reduce HepG2 cell survivability

• Dipanwita Sengupta, Kaustav Dutta Chowdhury, +4 authors Gobinda Chandra Sadhukhan
• Apoptosis
• 2017

Cancer cells often have faulty apoptotic pathways resulting in sustenance of survivability, tumour metastasis and resistance to anticancer drugs. Alternate strategies are sought to improve… (More)

Treatment with garlic restores membrane thiol content and ameliorates lead induced early death of erythrocytes in mice.

• Avik Sarkar, Dipanwita Sengupta, Samir K Mandal, Gargi Sen, Kaustav Dutta Chowdhury, Gobinda Chandra Sadhukhan
• Environmental toxicology
• 2015

Sequelae of chronic lead (Pb(2+) ) toxicity includes anemia that is partially due to early death of erythrocytes characterized by excess accumulation of ROS and downregulation of antioxidant system… (More)

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