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Previous studies suggested that aprotinin might enhance the host's immunological resistance to tumours. This possibility has now been further investigated by studying the behaviour of tumours in both hamsters and mice. A second tumour graft in tumour-bearing hamsters appeared more rapidly than the first. Prior administration of aprotinin abolished this(More)
The surface of single cells isolated from solid tumours by either a mechanical or an enzymatic method have been compared, using lactoperoxidase-catalyzed radioiodination of the tyrosine-containing proteins. Qualitatively, the patterns of surface labelling were similar, and duplicate experiments indicated that each method of isolation gave reproducible(More)
Methods have been developed which isolate single viable cells from the primary growths of two tumour systems (a lymphosarcoma and a carcinoma) and their secondary deposits. Subsequent comparisons of the surface-membrane structure of pairs of these primary and secondary cells, using lactoperoxidase-catalysed radioiodination coupled with polyacrylamide-gel(More)
Present evidence suggests that the cell surface has an important role in metastasis. To examine this idea further, the surface properties of single cells isolated from the primary growths of a liver-metastasizing (ML) and a non-metastasizing (NML) lymphosarcoma were compared for adhesion to cell monolayers, cytopherometry, isoelectric focusing, adhesion to(More)
The protein and glycoprotein composition of Triton X-100 extracts of breast biopsies from 17 women with benign breast disease and from 11 women with invasive breast carcinoma were investigated using electrophoresis in SDS-containing gradient polyacrylamide gels, followed by Coomassie Blue (CB) staining and the binding of radio-iodinated wheat germ(More)
PROTEASE inhibitors have been shown to inhibit tumour growth (Latner et al., 1974; Verloes et al., 1978) and invasiveness (Latner et al., 1973) in animal model systems. In addition, other recent evidence (Latner & Turner, 1976; Burden et al., 1978) has suggested that these substances may be operating in cancer by stimulating the host's immunological(More)
Software as a Service (SaaS) delivery model has become widespread. This deployment model changes the economics of software delivery but also has an impact on development. Releasing updates to customers is immediate and the development, product and marketing teams have access to customer usage information. These dynamics create a fast feedback loop between(More)
— this paper provides an industry case study for measuring the performance of software as a service (SaaS) product features in order to prioritize development efforts. The case is based on empirical data from HubSpot and it is generalized to provide a framework applicable to other companies with large scale software offerings and distributed development.(More)
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