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Cardiovascular derangements during sepsis may arise from a mismatch between endothelin (ET) and nitric oxide (NO). We hypothesized that progression of chronic peritoneal sepsis would affect cardiac performance and would modulate the concentrations of NO and ET in the heart and plasma. Male Sprague-Dawley rats (340-390 g) were catheterized and made septic(More)
The role of nitric oxide (NO) in the cardiovascular actions of diaspirin cross-linked hemoglobin (DCLHb) was studied in anesthetized rats. The regional circulatory and systemic hemodynamic effects of DCLHb (400 mg/kg iv) were studied using a radioactive microsphere technique in control (untreated) and L-arginine (a NO precursor) pretreated rats. DCLHb(More)
Antianxiety effect of noncompetitive NMDA receptor antagonist MK 801 was investigated on elevated plus-maze paradigm in rats. Interactional effects of MK 801 with the specific anxiolytic agent, diazepam; the anxiogenic beta-carboline agent, FG-7142 and the central BZ receptor antagonist Ro 15-1788 were explored. MK 801 (0.025-0.1 mg/kg) produced anxiolytic(More)
BACKGROUND To identify vascular beds where endogenous adenosine plays a significant role as a mediator of resting perfusion alterations associated with sepsis, we tested the hypothesis that adenosine receptor blockade would cause differential regional increases in vascular resistance during intraperitoneal (ip) sepsis in the rat. MATERIALS AND METHODS(More)
Opioid receptor antagonists can act centrally and peripherally. It is unclear if these 2 pathways differentially mediate the perfusion-associated effects of opioid antagonism during endotoxemia. Male, Sprague-Dawley rats (340-390 g) were surgically prepared with left ventricular, tail artery, and jugular vein catheters 24 h before experiments were begun.(More)
Electroencephalographic (EEG) activity in neocortex of rats following intracerebroventricular (icv) administration of NMDA (0.25-2 nmol/10 microliters) and its modification by noncompetitive NMDA-receptor antagonists, dizocilpine (MK-801) (0.025-0.1 mg/kg, ip) and ketamine (10-50 mg/kg, ip) was recorded at 0, 0.5, 4, 8 and 24 hr with chronically implanted(More)
Diaspirin crosslinked hemoglobin (DCLHb) (400 mg/kg, i.v.) produces an increase in blood pressure and blood flow to the heart, spleen, stomach, small intestine, skin, mesentery and pancreas when administered to rats. The present study was conducted to determine (1) whether prazosin, an alpha 1-adrenergic antagonist, can block the pressor effect of DCLHb and(More)
1. The effect of drugs affecting learning and memory was investigated using transfer latency (TL) as parameter for acquisition and retention of memory process on elevated plus-maze both in rats and mice. Further the validity of the procedure was envisaged. 2. The results provide an evidence for utility of shortened TL on 2nd day trial in old rats and mice(More)
Chronic peritoneal sepsis in a rodent model produces myocardial dysfunction characterized by decreased rates of ventricular contraction and relaxation in the isolated heart preparation. However, it remains controversial whether the ventricular contractility is altered during sepsis. In the present study, we determined the effect of chronic peritoneal sepsis(More)
Endotoxemia and sepsis often result in circulatory derangements which manifest as perfusion maldistributions. It has been widely accepted that the splanchnic circulation decreases in perfusion during advanced septic or endotoxemic states. Impaired perfusion of splanchnic organs may result not only in organ dysfunction but also exacerbations of polymicrobial(More)