Author Eric M. Wood

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PURPOSE To investigate UV filter synthesis in the human lens, in particular the biosynthetic origin of the second most abundant UV filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-beta-D-glucoside. METHODS Human lenses were analyzed by high-performance liquid chromatography (HPLC) after separate incubation with 3H-tryptophan (3H-Trp),(More)
Primate lenses are unique in that they convert tryptophan (trp) into 3-hydroxykynurenine glucoside (30HKG). This is the major short-wave absorbing pigment present in human lenses and it may play a role in protecting the eye from UV-induced photodamage. A study has been performed on aspects of this metabolic pathway in human lenses. A significant rate of(More)
Experiments have been conducted on various aspects of the biosynthetic pathway leading to the formation of 3-hydroxykynurenine glucoside (3OHKG), the major tryptophan-derived human lens UV filter compound. Measurable levels of the reactive metabolite, 3-hydroxykynurenine (3OHKyn) were found in normal human lenses, including lens nuclei. 3OHKyn was able to(More)
A new UV-filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside, has been identified in human lenses. The structure suggests that it is derived biosynthetically from tryptophan. Quantification studies on the new compound show that it is the second-most abundant UV-filter compound in the lens with an absorption and fluorescence spectrum(More)
Although free tryptophan was found in the lens of both the kissing gourami (Helostoma temmincki) and the 3-spot gourami (Trichogaster trichopterus), only the lens of the latter species contained 3-hydroxykynurenine. Radiolabel experiments carried out on 3-spot gourami lenses in culture demonstrated that, as in humans, lenticular tryptophan is converted to(More)
BioOne ( is a nonprofit, online aggregation of core research in the biological, ecological, and environmental sciences. BioOne provides a sustainable online platform for over 170 journals and books published by nonprofit societies, associations, museums, institutions, and presses. Abstract. California oak savanna is a habitat of sparse tree(More)
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