Austin Mcelroy

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Non-invasive depth-resolved measurement of hemoglobin oxygen saturation (SaO(2)) levels in discrete blood vessels may have implications for diagnosis and treatment of various pathologies. We introduce a novel Dual-Wavelength Photothermal (DWP) Optical Coherence Tomography (OCT) for non-invasive depth-resolved measurement of SaO(2) levels in a blood vessel(More)
Microvasculature hemoglobin oxygen saturation (SaO2) is important in the progression of various pathologies. Non-invasive depth-resolved measurement of SaO2 levels in tissue microvasculature has the potential to provide early biomarkers and a better understanding of the pathophysiological processes allowing improved diagnostics and prediction of disease(More)
New optical imaging techniques that provide contrast to study both the anatomy and composition of atherosclerotic plaques can be utilized to better understand the formation, progression and clinical complications of human coronary artery disease. We present a dual-modality fiber-based optical imaging system for simultaneous microstructural and molecular(More)
AIM To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. MATERIALS & METHODS Thin conducting composite biomaterials based on multilayer films of poly(3.4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with(More)
BACKGROUND AND OBJECTIVES Atherosclerosis and plaque rupture leads to myocardial infarction and stroke. A novel hybrid optical coherence tomography (OCT) and two-photon luminescence (TPL) fiber-based imaging system was developed to characterize tissue constituents in the context of plaque morphology. STUDY DESIGN/MATERIALS AND METHODS Ex vivo coronary(More)
METHODS A custom-built, rotational, 3-French, hybrid IVUS-OCT imaging catheter was used for image acquisition. A 40 MHz ultrasound transducer located at the tip of the catheter contained an embedded OCT fiber optic cable in order to generate coincident imaging beams. The catheter is capable of obtaining simultaneous coregistered IVUS-OCT images in a single(More)
Distinct reference and signal interferometers in combination with a gas-cell spectral reference are employed to increase sensitivity and environmental stability of a swept source phase-sensitive optical coherence tomography. A displacement sensitivity (DS) of 65 pm at 280-μm depth and DS degradation with depth of 0.0015 rad/mm is achieved.(More)
BACKGROUND AND OBJECTIVE Surgical oncology can benefit from specialized tools that enhance imaging and enable precise cutting and removal of tissue without damage to adjacent structures. The combination of high-resolution, fast optical coherence tomography (OCT) co-aligned with a nanosecond pulsed thulium (Tm) laser offers advantages over conventional(More)
A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm(More)
Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of(More)