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Many breast cancer cells acquire multidrug resistance (MDR) mediated by ABC transporters such as breast cancer resistance protein (BCRP/ABCG2). Here we show that incubation of human breast cancer MDA-MB-231 cells with farnesoid X receptor antagonist guggulsterone (gug) and retinoid X receptor agonist bexarotene (bex) elevated ceramide, a sphingolipid known(More)
As embedded systems continue to evolve, Java becomes an attractive alternative to traditional languages for embedded hardware platforms. However, there are a number of obstacles for Java to hurdle in order to fulfill all the requirements of any real-time embedded systems. This paper presents an architectural view of a memory design for the embedded Java(More)
Despite modern advances, a broad range of disorders such as cancer and infectious diseases continually afflict the global population. Novel therapeutics are continuously being explored to address these challenges. Therefore, scalable, effective, and safe therapies that are readily accessible to third-world countries are of major interest. In this article,(More)
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