Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
The ground state of embryonic stem cell self-renewal
It is shown that extrinsic stimuli are dispensable for the derivation, propagation and pluripotency of ES cells and reveal that ES cells have an innate programme for self-replication that does not require extrinsics instruction.
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
A role is established for Oct-3/4 as a master regulator of pluripotency that controls lineage commitment and the sophistication of critical transcriptional regulators is illustrated and the consequent importance of quantitative analyses are illustrated.
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
- Qi-Long Ying, M. Stavridis, Dean S. Griffiths, M. Li, Austin G Smith
- BiologyNature Biotechnology
- 13 January 2003
It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
DIA and human interleukin DA/leukaemia inhibitory factor have been identified as related multifunctional regulatory factors with distinct biological activities in both early embryonic and haemopoetic stem cell systems.
Naive and primed pluripotent states.
Klf4 reverts developmentally programmed restriction of ground state pluripotency
Mouse embryonic stem cells derived from pluripotent early epiblast contribute functionally differentiated progeny to all foetal lineages of chimaeras and were maintained after Cre-mediated deletion of the Klf4 transgene, formally demonstrating complete and stable reprogramming of developmental phenotype.
Nanog Is the Gateway to the Pluripotent Ground State