• Publications
  • Influence
The ground state of embryonic stem cell self-renewal
TLDR
It is shown that extrinsic stimuli are dispensable for the derivation, propagation and pluripotency of ES cells and reveal that ES cells have an innate programme for self-replication that does not require extrinsics instruction.
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
TLDR
A role is established for Oct-3/4 as a master regulator of pluripotency that controls lineage commitment and the sophistication of critical transcriptional regulators is illustrated and the consequent importance of quantitative analyses are illustrated.
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
TLDR
It is reported that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate and this system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuronal and glial cell production from pluripotent mammalian stem cells.
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
TLDR
DIA and human interleukin DA/leukaemia inhibitory factor have been identified as related multifunctional regulatory factors with distinct biological activities in both early embryonic and haemopoetic stem cell systems.
Klf4 reverts developmentally programmed restriction of ground state pluripotency
TLDR
Mouse embryonic stem cells derived from pluripotent early epiblast contribute functionally differentiated progeny to all foetal lineages of chimaeras and were maintained after Cre-mediated deletion of the Klf4 transgene, formally demonstrating complete and stable reprogramming of developmental phenotype.
...
...