Austin D Collins

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Using a microarray platform for allergy diagnosis allows for testing of specific IgE sensitivity to a multitude of allergens, while requiring only small volumes of serum. However, variation of probe immobilization on microarrays hinders the ability to make quantitative, assertive, and statistically relevant conclusions necessary in immunodiagnostics. To(More)
Central areolar choroidal dystrophy (CACD) is a rare inherited retinal disease which causes progressive profound loss of vision in patients during their 4th decade. We have identified a Northern Irish family with 19 affected individuals in three living generations. We have performed a total genome search and established linkage of CACD in this family to(More)
Transplant coronary artery disease (TxCAD) is manifest as a diffuse, concentric intimal proliferation which results in occlusion of the allograft vessel lumen, and is responsible for limiting the long-term success of cardiac transplantation. The recent discovery of high circulating levels of anti-endothelial antibodies (AEAs) in patients with TxCAD has(More)
Allergy is a disorder of the immune system characterized by a maladaptive immune response to harmless environmental antigens (“allergens”). Allergy affects nearly 40–50 million people in the US, with total estimated costs attributable to asthma care at $19.7B [1,2]. Phadia AB is the market leader in allergy in vitro diagnostics with the(More)
Single-crystal X-ray methods have been used to characterize a nickel derivative of adenosine 5'-monophosphate, of stoicheiometry [Ni(5'-AMP)(H2O)5]-H2O. The metal atom binds to the N(7) position on the adenine base, with the five remaining octahedral coordination sites about nickel occupied by water molecules. The phosphate group is connected via(More)
Plateletscirculateas flat oval discs which, upon stimulation with a variety of agents including ADP, thrombin, collagen and glass, transform into compact spheres from which extend spikes (filopodia) and veils [ 1 1. These changes in platelet morphology result from reorganization of the cytoskeleton. In addition to generating shape changes and tension. the(More)
High circulating levels of anti-endothelial antibodies have been reported in patients with accelerated transplant coronary artery disease (TxCAD); however, the nature or characteristics of the antigen to which these antibodies bind in vivo remain unclear. To identify the antigen, a human endothelial cell cDNA expression library was constructed in lambdaZAP(More)
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