Aurelio Pinheiro

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AIMS Several mutations in the ventricular myosin regulatory light chain (RLC) were identified to cause familial hypertrophic cardiomyopathy (FHC). Based on our previous cellular findings showing delayed calcium transients in electrically stimulated intact papillary muscle fibres from transgenic Tg-R58Q and Tg-N47K mice and, in addition, prolonged force(More)
OBJECTIVES To quantify resting myocardial blood flow (MBF) in the left ventricular (LV) wall of HCM patients and to determine the relationship to important parameters of disease: LV wall thickness, late gadolinium enhancement (LGE), T2-signal abnormalities (dark and bright signal), LV outflow tract obstruction and age. MATERIALS AND METHODS Seventy(More)
OBJECTIVE This study was designed to examine the utility of two-dimensional strain (2DS) or speckle tracking imaging to typify functional adaptations of the left ventricle in variant forms of left ventricular hypertrophy (LVH). DESIGN Cross-sectional study. SETTING Urban tertiary care academic medical centres. PARTICIPANTS A total of 129 subjects, 56(More)
By cardiac MRI we investigated the relationship of resting myocardial blood flow (MBF) in hypertrophic cardi-omyopathy (HCM) patients to important parameters of disease. MBF was quantified on pixel-by-pixel basis in 804 segments in 70 patients. Relative MBF negatively correlated with left-ventricular (LV) wall thickness (p<0.001), extent of myocardial(More)
The American Heart Association has recommended a 12-element questionnaire for pre-participation screening of athletes (before they take on athletic activities), in order to reduce and hopefully prevent sudden cardiac death in young athletes. This screening procedure is widely used throughout the United States, but its efficacy for discriminating Normal from(More)
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