Aurel Ardelean

Learn More
This study evaluated the in vitro effects of 62.5 µg/mL silica nanoparticles (SiO NPs) on MRC-5 human lung fibroblast cells for 24, 48 and 72 h. The nanoparticles' morphology, composition, and structure were investigated using high resolution transmission electron microscopy, selected area electron diffraction and X-ray diffraction. Our study showed a(More)
The present study investigated the capacity of formulated Berberis vulgaris extract/β-cyclodextrin to protect liver against CCl(4)-induced hepatotoxicity in mice. Formulated and non-formulated extracts were given orally (50 mg/kg/day) to mice for 7 days and were then intra-peritoneally injected with 1.0 mL/kg CCl(4) on the 8th day. After 24 h of CCl(4)(More)
MOTIVATION Recent studies indicate that fractal dimensions can uncover aspects of cellular dynamics prior to pathological manifestation. In this respect we are interested in building a computational model of oncogenesis able to generate patterns with the same fractal dimension spectrum as the in vivo tumor. RESULTS A new theoretical model incorporating a(More)
A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Background Pneumococcal meningitis (PM) is a life-threatening disease. Recurrent PM is relatively rare and associated with predisposing conditions. This study analyzed the outcome of patients with recurrent versus non-recurrent PM.(More)
The biochemical and histopathological changes induced by the exposure to iron oxide nanoparticles coated with phospholipid-based polymeric micelles (IONPs-PM) in CD-1 mice lungs were analyzed. After 2, 3, 7 and 14 days following the intravenous injection of IONPs-PM (5 and 15 mg Fe/kg bw), lactate dehydrogenase (LDH) activity, oxidative stress parameters(More)
The concept is an universal manner of representation, and as idea it is the " witness " of reality. Treated according to a theory of definition, concepts are formal/as ideas, objective/in the sense of objects, hybrid/as structures and migratory/as dynamics. The concepts " substantiate " disciplinarity, and their nature " rebuilds " ① Disciplinarity/unity(More)
Introduction. The present study fills a gap in the Romanian bio-medical research domain through a global and unitary investigation of aging processes in the central nervous system (CNS) of both humans and animals, from macroscopic-regional-zonal levels to tissual-cellular-subcellular ones. In addition, the determination of correlations with Alzheimer(More)
  • 1