Aurel Ardelean

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The existence of the epicardial telocytes was previously documented by immunohistochemistry (IHC) or immunofluorescence. We have also demonstrated recently that telocytes are present in mice epicardium, within the cardiac stem-cell niches, and, possibly, they are acting as nurse cells for the cardiomyocyte progenitors. The rationale of this study was to(More)
During the last few years, there is an increasing interest in the role of the epicardium in cardiac development, myocardial remodelling or repair and regeneration. Several types of cells were described in the subepicardial loose connective tissue, beneath the epicardial mesothe-lium. We showed previously (repeatedly) the existence of interstitial Cajal-like(More)
The present study investigated the capacity of formulated Berberis vulgaris extract/β-cyclodextrin to protect liver against CCl(4)-induced hepatotoxicity in mice. Formulated and non-formulated extracts were given orally (50 mg/kg/day) to mice for 7 days and were then intra-peritoneally injected with 1.0 mL/kg CCl(4) on the 8th day. After 24 h of CCl(4)(More)
This study evaluated the in vitro effects of 62.5 µg/mL silica nanoparticles (SiO NPs) on MRC-5 human lung fibroblast cells for 24, 48 and 72 h. The nanoparticles' morphology, composition, and structure were investigated using high resolution transmission electron microscopy, selected area electron diffraction and X-ray diffraction. Our study showed a(More)
MOTIVATION Recent studies indicate that fractal dimensions can uncover aspects of cellular dynamics prior to pathological manifestation. In this respect we are interested in building a computational model of oncogenesis able to generate patterns with the same fractal dimension spectrum as the in vivo tumor. RESULTS A new theoretical model incorporating a(More)
A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Background Pneumococcal meningitis (PM) is a life-threatening disease. Recurrent PM is relatively rare and associated with predisposing conditions. This study analyzed the outcome of patients with recurrent versus non-recurrent PM.(More)
The biochemical and histopathological changes induced by the exposure to iron oxide nanoparticles coated with phospholipid-based polymeric micelles (IONPs-PM) in CD-1 mice lungs were analyzed. After 2, 3, 7 and 14 days following the intravenous injection of IONPs-PM (5 and 15 mg Fe/kg bw), lactate dehydrogenase (LDH) activity, oxidative stress parameters(More)
The concept is an universal manner of representation, and as idea it is the " witness " of reality. Treated according to a theory of definition, concepts are formal/as ideas, objective/in the sense of objects, hybrid/as structures and migratory/as dynamics. The concepts " substantiate " disciplinarity, and their nature " rebuilds " ① Disciplinarity/unity(More)
An ordinary differential equations (ODE) system describing the oscillation dynamics of a neuronal network is numerically integrated aiming to evidence chaos by the change in sign from negative to positive of the maximum Lyapunov exponents, and by a sudden decrease in the error doubling time. The error doubling time is calculated for different frequencies of(More)
Introduction. The present study fills a gap in the Romanian bio-medical research domain through a global and unitary investigation of aging processes in the central nervous system (CNS) of both humans and animals, from macroscopic-regional-zonal levels to tissual-cellular-subcellular ones. In addition, the determination of correlations with Alzheimer(More)
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