Augustus R. Hall

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Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this(More)
Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as the sarcoplasmic reticulum (SR). Inhibiting mitochondrial fission can protect the heart against acute ischemia/reperfusion (I/R) injury. However, the(More)
Quaternary interactions of p53 influence its tertiary structure which, in turn, is critical for sequence-specific DNA binding and tumour suppressor function. Given its regulatory potential we have sought to define the quaternary structure of p53 involved in sequence-specific DNA binding. Double stranded DNA [5'-GGACATGCCCGGGCATGTCC-3'; Funk et al. (1992)(More)
Novel therapeutic targets are required to protect the heart against cell death from acute ischemia-reperfusion injury (IRI). Mutations in the DJ-1 (PARK7) gene in dopaminergic neurons induce mitochondrial dysfunction and a genetic form of Parkinson's disease. Genetic ablation of DJ-1 renders the brain more susceptible to cell death following(More)
IT IS notoriously difficult to deal clearly and accurately with the history of controversy over priority, and the dispute over priority in blood transfusion recently explored by Dr. A. D. Farr in this journal is no exception.' The story has often been told from various points of view:2 and we ourselves printed many documents connected with the controversy(More)
Sequence-specific DNA binding by p53 is dependent upon protein conformation. The 1620+ form correlates with wild type p53 suppressor function and is a prerequisite for binding to the DNA consensus p53-CON in vitro. It has been reported that murine p53 changes conformation on interaction with high affinity DNA target sequences and in the present study we(More)
By A. E. Hail, Assistant Surgeon, Royal Artillery. This i3 a question which has been often asked, but which does not appear to have been answered satisfactorily. Waring, in his " Manual of Practical Therapeutics," page 296, tells us that " ipecacuanha possesses considerable sedative powers, as is shown by its influence in hajmorrliagic diseases ;" and at(More)
By A. R. Hall, Assistant Surgeon, lloyal Artillery. The article on tliis subject, by Assistant, Surgeon Candy, M.D., 109th Regiment, published in the Indian Medical Gazette for July, recommends a plan of treatment, which it wns to be hoped had been given up as worse than useless by those who had had experience of this disease. Blood-lettin?, tartar-emetic,(More)
given to the patient in large quantities, without doing any permanent benefit. The late Professor Parkes, in his book published in 1847, entitled Researches into the Pathology and Treatment of the Asiatic or Algide Cholera, was the first who directed particular attention to the state of the lungs and heart in this fatal disease. And Professor George(More)