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- Vincenzo Bronte, Sven Brandau, +12 authors Dmitry I Gabrilovich
- Nature communications
- 2016
Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions… (More)
- P Cabanas RodrÃguez, Marc S. Ernstoff, +4 authors Augusto Ochoa
- Cancer research
- 2009
Myeloid-derived suppressor cells (MDSC) producing arginase I are increased in the peripheral blood of patients with renal cell carcinoma (RCC). MDSC inhibit T-cell function by reducing the… (More)
- Arnold H. Zea, P Cabanas RodrÃguez, +9 authors Augusto Ochoa
- Cancer research
- 2005
Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. These cells, described as macrophages or immature dendritic cells, deplete… (More)
- P Cabanas RodrÃguez, David G. Quiceno, +10 authors Augusto Ochoa
- Cancer research
- 2004
T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and a decreased production of cytokines. The mechanisms causing these… (More)
- P Cabanas RodrÃguez, Claudia P. Hernandez, +5 authors Augusto Ochoa
- The Journal of experimental medicine
- 2005
Myeloid suppressor cells (MSCs) producing high levels of arginase I block T cell function by depleting l-arginine in cancer, chronic infections, and trauma patients. In cancer, MSCs infiltrating… (More)
- Ilona Kryczek, Linhua Zou, +12 authors Weiping Zou
- The Journal of experimental medicine
- 2006
Tumor-associated macrophages are a prominent component of ovarian cancer stroma and contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show that primary ovarian… (More)
- Dmitry I Gabrilovich, Vincenzo Bronte, +4 authors Hans Schreiber
- Cancer research
- 2007
The recent study by Yang et al. (1) described antigen-specific immunosuppression by Gr-1CD11b myeloid cells, which was mediated by the expression of CD80. This report continued a series of recent… (More)
Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon… (More)
- P Cabanas RodrÃguez, Augusto Ochoa
- Immunological reviews
- 2008
Patients with cancer have an impaired T-cell response that can decrease the potential therapeutic benefit of cancer vaccines and other forms of immunotherapy. L-arginine (L-Arg) is a conditionally… (More)
- Steven L Highfill, P Cabanas RodrÃguez, +10 authors Bruce R Blazar
- Blood
- 2010
Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that accumulate in the tissue of tumor-bearing animals and are known to inhibit immune responses. Within 4 days, bone… (More)