Augusto Ochoa

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Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma

P Cabanas Rodríguez, Claudia P. Hernandez, +5 authors Augusto Ochoa
The Journal of experimental medicine
2005

Myeloid suppressor cells (MSCs) producing high levels of arginase I block T cell function by depleting l-arginine in cancer, chronic infections, and trauma patients. In cancer, MSCs infiltrating… (More)

Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses.

P Cabanas Rodríguez, David G. Quiceno, +10 authors Augusto Ochoa
Cancer research
2004

T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and a decreased production of cytokines. The mechanisms causing these… (More)

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

Vincenzo Bronte, Sven Brandau, +12 authors Dmitry I Gabrilovich
Nature communications
2016

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions… (More)

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma

Ilona Kryczek, Linhua Zou, +12 authors Weiping Zou
The Journal of experimental medicine
2006

Tumor-associated macrophages are a prominent component of ovarian cancer stroma and contribute to tumor progression. B7-H4 is a recently identified B7 family molecule. We show that primary ovarian… (More)

Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.

P Cabanas Rodríguez, Marc S. Ernstoff, +4 authors Augusto Ochoa
Cancer research
2009

Myeloid-derived suppressor cells (MDSC) producing arginase I are increased in the peripheral blood of patients with renal cell carcinoma (RCC). MDSC inhibit T-cell function by reducing the… (More)

Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion.

Arnold H. Zea, P Cabanas Rodríguez, +9 authors Augusto Ochoa
Cancer research
2005

Myeloid suppressor cells with high arginase activity are found in tumors and spleen of mice with colon and lung cancer. These cells, described as macrophages or immature dendritic cells, deplete… (More)

The terminology issue for myeloid-derived suppressor cells.

Dmitry I Gabrilovich, Vincenzo Bronte, +4 authors Hans Schreiber
Cancer research
2007

The recent study by Yang et al. (1) described antigen-specific immunosuppression by Gr-1CD11b myeloid cells, which was mediated by the expression of CD80. This report continued a series of recent… (More)

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.

P Cabanas Rodríguez, Augusto Ochoa
Immunological reviews
2008

Patients with cancer have an impaired T-cell response that can decrease the potential therapeutic benefit of cancer vaccines and other forms of immunotherapy. L-arginine (L-Arg) is a conditionally… (More)

Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice.

Hideaki Mizoguchi, John J O'Shea, Dan L. Longo, C. M. Loeffler, Daniel W McVicar, Augusto Ochoa
Science
1992

Impaired immune responses occur frequently in cancer patients or in tumor-bearing mice, but the mechanisms of the tumor-induced immune defects remain poorly understood. In an in vivo murine colon… (More)

L-arginine availability regulates T-lymphocyte cell-cycle progression.

P Cabanas Rodríguez, David G. Quiceno, Augusto Ochoa
Blood
2007

L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion by myeloid-derived suppressor cells producing arginase I is seen in… (More)

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