Augusto César Aragão Oliveira

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A series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The structure-activity relationship (SAR) analysis indicated the number, the positions, and the types of substituents attached to the aromatic ring as being critical factors(More)
Dengue fever frequently presents with non specific symptoms, making it difficult to be distinguished from other acute febrile illnesses, including leptospirosis. Given this, serum samples from 82 patients with clinical features of dengue-like illness were evaluated for dengue infection by IgM-enzyme-linked immunosorbent assay (ELISA) and reverse(More)
In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC50) ranged from 0.82 to 12.90 μM. The compound (E)-N′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed(More)
Leptospirosis is a febrile disease with a typically underestimated global incidence, especially in regions where dengue is endemic. Therefore, it is difficult to accurately determine the number of leptospirosis cases in these areas, which contributes to significant under-reporting this disease. In this study, we estimated the number of possible(More)
Twenty-two hydroxyethylamine derivatives ((2S,3R)-2-(Amino)-[4-(N-benzylarenesulfonamido)-3-hydroxy-1-phenylbutane derivatives) containing aromatic sulfonamides were evaluated for their cytotoxic potential against three cancer cell lines using MTT assay. All compounds containing the Boc group, with the exception of 4i, were inactive at 5 μg/mL against all(More)
1. Curso de Medicina, Universidade de Fortaleza, Fortaleza, CE. 2. Departamento de Patologia e Medicina Legal, Universidade Federal do Ceará, Fortaleza, CE. 3. Centro de Pesquisa em Virologia, Faculdade de Medicina, Universidade de São Paulo, Ribeirão Preto, SP. 4. Setor de Virologia, Laboratório Central de Saúde Pública do Estado do Ceará, Fortaleza, CE.(More)
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