Augustine O. Okhamafe

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BACKGROUND Malaria remains one of the most important causes of maternal and child morbidity and mortality in sub-Saharan Africa, despite the availability of effective interventions. The objective of this study was to assess the knowledge, attitude and practice of malaria management among pregnant women attending antenatal clinics in Nigeria. METHODS A(More)
SUMMARY This study evaluated malaria care-seeking behaviour, as well as the prevalence of parasitaemia and anaemia among pregnant women attending antenatal clinics of two tertiary healthcare facilities in Edo State, Nigeria. Malaria was highly prevalent in the study group (20% by microscopy and estimated 25% by PCR), but parasitaemia and incidence decreased(More)
This study investigated anti-malarial prophylaxis during pregnancy and children's malaria care-seeking behaviour by mothers with children 5 y of age and below drawn from 2 rural communities in southern Nigeria. Findings showed that 37% of mothers said they had used anti-malarial prophylaxis (chloroquine, 50%) during pregnancy, while only 30% of them had bed(More)
Three methods--radiotracer, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA)--have been employed to evaluate moisture interactions in aqueous-based hydroxypropyl methylcellulose films containing polyethylene glycol 400, polyethylene glycol 1000 or polyvinyl alcohol. The radiotracer employed was tritiated water. Using a proposed(More)
Interaction phenomena, in aqueous-based hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) film-coating formulations containing water-soluble additives (citric acid and urea) have been examined by thermal methods to assess glass transition, softening, melting, plasticization, and crystallinity. The methods used were differential scanning(More)
Some probable consequences of the dissolution/migration of a major solid dosage component in or into an applied film coating during or after a film coating operation have been investigated using free films of hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) incorporating small amounts of either lactose (a diluent) or ephedrine hydrochloride(More)
OBJECTIVE To investigate the prevalence of malaria during pregnancy and antimalarial interventions in an urban secondary health care facility. SUBJECTS AND METHODS Of 432 pregnant women who delivered or were attending an antenatal clinic in a secondary health care facility in Benin City, Nigeria, 199 were recruited for the study. Demographic data were(More)
Moisture permeation parameters--diffusion, solubility and permeation coefficients--for hydroxypropyl methylcellulose (HPMC) and partially hydrolyzed polyvinyl alcohol (PVA) films containing either of two water-soluble additives (citric acid and urea) have been evaluated from transmission and time lag data. Contrary to expectations, the moisture(More)
The Brinell hardness and Young's modulus of pigmented and unpigmented films of hydroxypropyl methylcellulose alone, and in combination with either polyethylene glycol 400 (plasticizer) or polyvinyl alcohol, which were applied to aspirin tablets, have been measured. Generally hardness and modulus data showed similar trends. The hardness and modulus of(More)