Augusta A Mikhailova

  • Citations Per Year
Learn More
Myelopeptides (MPs) are bioregulatory mediators of bone marrow origin. Several individual MPs have been isolated from the supernatant of porcine bone marrow cell culture by successive solid phase extraction and reversed-phase high performance liquid chromatography. Two of them, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp), were(More)
Along with known lymphokines involved in the regulation of hematopoiesis, a new differentiating factor (myelopeptide-4, MP-4) for myeloid cells was found. The peptide (Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro) originally isolated from the culture medium of porcine bone marrow cell culture was examined for its ability to induce differentiation in two human myeloid(More)
Bone marrow cells produce soluble mediators with structural and functional heterogeneity. They were found to stimulate antibody production at the peak of the immune response, owing to compounds of a peptide nature (Mr 2000-1300). Active material was isolated by means of gel chromatography and electrophoresis. This material positively reacts with ninhydrin,(More)
The time-course of the structure of nocturnal sleep in normal subjects in conditions of a single sleep deprivation (acute sleep deprivation) and in neurotic patients with chronic sleep deprivation has been studied. The efficacy of acupuncture under different conditions is analyzed. The results obtained suggest a differential nature of the acupuncture effect(More)
Myelopeptides (MPs) are low-molecular-weight immunoregulatory peptides of bone marrow origin. The peculiarities of their immunoregulatory effects are demonstrated with two of the six synthesized MPs, MP-1 (Phe-Leu-Gly-Phe-Pro-Thr) and MP-2 (Leu-Val-Val-Tyr-Pro-Trp). It is shown that MP action is directed to the damaged links of immunity. MP-1 enhances a(More)
We studied the effect of endogenous immunoregulatory myelopeptide-2 on the development of spontaneous and urethane-induced lung adenomas. Long-term treatment with myelopeptide-2 (25 injections) in parallel with urethane poisoning decreased animal mortality caused by this carcinogen. Short-term treatment with myelopeptide-2 decreased the number of(More)
Myelopeptide-4 (MP-4) (Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro), inducing the terminal differentiation of HL-60 leukemia cells, was labeled with fluorescein isothiocyanate. The specific binding of this modified peptide to the surface of HL-60 cells and its ability to penetrate into the cells were studied. It was shown by cytometry and confocal microscopy to be(More)
When the body is exposed to the action of unfavorable factors and, in particular, acute hypoxic hypoxia, which is a nonspecific stress factor, considerable changes take place in lymphoid tissue function [3]. Hematopoietic stem cells are redistributed and migration of T and B lymphocytes and their precursors from the central organs to the periphery is(More)
The status of the serotoninergic and catecholaminergic systems was studied in patients with neurotic depressive disorders before and after acupuncture (AP). The parameters studied included blood serotonin levels, monoamine oxidase (MAO) activity in the blood serum, as well as urinary excretion of adrenaline, noradrenaline, dopamine, DOPA and 5-HOIAA. Prior(More)
It was described earlier that in the tissue cultures of immune mouse LN cells the number of antibody producing cells was increased 2-3-fold when syngeneic of allogeneic nonimmune BM cells were included in the cultures. In these experiments, parallel mixed cultures were set up of mouse immune LN cells with non-immune BM cells of either syngeneic or(More)