August E. J. L. Kramer

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OBJECTIVES To evaluate the dose-response relationship and safety/tolerability of solifenacin succinate (YM905) in the treatment of overactive bladder (OAB), and to compare its efficacy and safety/tolerability with tolterodine 2 mg twice daily. PATIENTS AND METHODS This multicentre study included a 2-week single-blind placebo run-in, a 4-week double-blind(More)
A muscle model based on the sliding filament concept is put forward. The model is simplified in such a way that it may easily be simulated on a computer (analog or digital). The model shows quite a few muscle properties rather well e.g. Hill's relation, quick-stretch and quick-release series elasticity and some dynamic transfer properties. It is found that,(More)
A group of 72 female patients whose incontinence had persisted despite various therapies was selected for an extensive urodynamic study. Overt neuropathy was absent in the patient group. An objectified history was taken and the patients were categorized accordingly. Filling cystometry and flow studies were performed in supine and standing positions,(More)
Sixty unselected patients from two centers (40+20) with complaints indicating detrusor overactivity or hypersensitivity entered a prospective double-blind cross-over trial to test the efficacy of drug treatment. Two active drugs and a placebo were taken at random during consecutive 3-week periods. The active drugs used were emepronium bromide, which was(More)
In 26 patients with erectile impotence and 8 healthy volunteers the value of continuous monitoring of penile tumescence and rigidity by means of the RigiScan was tested. Based on history and routine screening tests the patients were divided into 3 groups of preliminary diagnosis: psychogenic (5 patients), organic (10 patients), mixed (11 patients).(More)
1. Rat soleus muscles (SOL) were isolated and the force-shortening curves were determined during isometric maximal tetani. These were measured by applying sudden shortenings of different magnitudes to one end of the muscle while recording the resulting drop in tension. 2. From the force-shortening curve a stiffness-force curve was derived. Then a(More)
A group of 75 non-neuropathic female patients with persisting complaints (71 incontinent and 4 urge patients) had been selected earlier for extensive urodynamic study. Based on an objectified history and urodynamic results, 28 patients were diagnosed as genuine stress incontinent (12 of whom showed urethral instability as well), 19 as motor urge incontinent(More)
The present discussion on the natural history, growth rate, pathophysiology, morbidity, and possible treatment of benign prostatic hyperplasia (BPH) reinforces the need to objectify mechanical BPH-induced obstruction with pressure-flow study. Different methods for the quantification of BPH-induced obstruction exist and the grade of simplification depends on(More)
An on-line personal computer (PC)-based expert system was constructed for pressure-flow study of the lower urinary tract. An “empty” expert-system “shell” and supplementary programs were used for this system; the latter served to compensate the defects of the “shell” and are referred to as data programs in this report. The data programs were written in the(More)
The urinary drop spectrometer is an instrument for detection of the external break-up pattern of the urinary stream. The circuitry described in this paper conditions the photodiode current pulses for recording on a f.m. instrumentation tape-recorder and provides the interface to feed the pulse intervals and pulse maxima into a PDP 11/10 l.p.s. signal(More)