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ZMM proteins during meiosis: Crossover artists at work

• Audrey Lynn, Rachel Soucek, G Valentin Börner
• Chromosome Research
• 2007

Faithful segregation of homologous chromosomes (homologs) during meiosis depends on chiasmata which correspond to crossovers between parental DNA strands. Crossover forming homologous recombination… (More)

Covariation of synaptonemal complex length and mammalian meiotic exchange rates.

• Audrey Lynn, Kara E. Koehler, +6 authors Terry J. Hassold
• Science
• 2002

Analysis of recombination between loci (linkage analysis) has been a cornerstone of human genetic research, enabling investigators to localize and, ultimately, identify genetic loci. However, despite… (More)

Variation in human meiotic recombination.

• Audrey Lynn, T Clay Ashley, Terry J. Hassold
• Annual review of genomics and human genetics
• 2004

As recently as 20 years ago, there was relatively little information about the number and distribution of recombinational events in human meiosis, and we knew virtually nothing about factors… (More)

Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains.

• Kara E. Koehler, Jonathan P. Cherry, Audrey Lynn, Patricia A Hunt, Terry J. Hassold
• Genetics
• 2002

Genetic background effects on the frequency of meiotic recombination have long been suspected in mice but never demonstrated in a systematic manner, especially in inbred strains. We used a recently… (More)

Mutations in CDMP1 cause autosomal dominant brachydactyly type C

• Alexander Polinkovsky, Nathaniel H Robin, +12 authors Matthew L Warman
• Nature Genetics
• 1997

A genome-wide linkage analysis investigating the determinants of blood pressure in whites and African Americans.

• Bonnie A. Thiel, Aravinda Chakravarti, +6 authors Alan B. Weder
• American journal of hypertension
• 2003

Evidence for genomic regions influencing systolic and diastolic blood pressure (BP) were assessed in a whole genome linkage analysis in 211 African American and 160 white families as part of the… (More)

Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3.

• Haiming Chen, Colette Rossier, +4 authors Stylianos E. Antonarakis
• American journal of human genetics
• 1996

In an effort to contribute to the transcript map of human chromosome 21 and the understanding of the pathophysiology of trisomy 21, we have used exon trapping to identify fragments of chromosome 21… (More)

Family history and perceptions about risk and prevention for chronic diseases in primary care: A report from the Family Healthware™ Impact Trial

• Louise S. Acheson, Catharine Wang, +6 authors Donald E. Nease
• Genetics in Medicine
• 2010

Purpose: To determine whether family medical history as a risk factor for six common diseases is related to patients' perceptions of risk, worry, and control over getting these diseases.Methods: We… (More)

Cytological studies of meiotic recombination in human males.

• Terry J. Hassold, Luann Judis, Ernest R. Chan, Stuart Schwartz, Allen D. Seftel, Audrey Lynn
• Cytogenetic and genome research
• 2004

We combined immunostaining and fluorescence in situ hybridization (FISH) methodology to directly examine meiotic exchanges in over 2,000 pachytene stage spermatocytes from 25 individuals. Our results… (More)

Sex, not genotype, determines recombination levels in mice.

• Audrey Lynn, Stefanie E. Schrump, Jonathan P. Cherry, Terry J. Hassold, Patricia A Hunt
• American journal of human genetics
• 2005

Recombination, the precise physical breakage and rejoining of DNA between homologous chromosomes, plays a central role in mediating the orderly segregation of meiotic chromosomes in most eukaryotes.… (More)

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