Audrey Lemoine

Learn More
This study examined the effects, after 1 min or 2 hr, of one footshock session on the activity of MAO in rat heart and brain, the MAO inhibitory activity of these tissues, and the animal's behavior in an open field. Internal ambulation was reduced at both times; the lowest score was registered at 1 min. The number of boluses emitted during the test was(More)
1. The effect of benzodiazepine pretreatment on the stress-induced decrease in MAO activity in rat tissues using footshock as stress model was investigated. 2. Animals were injected with vehicle, Lorazepam (1.25 mg/kg), or Clonazepam (0.5 mg/kg) 2 hr before or with PK 11195 (0.45 mg/kg) 2.5 hr before being subjected to one session of 10 inescapable(More)
1. The effect of repeated isolation stress on MAO inhibitory activity (tribulin) in rat tissues as well as on plasma catecholamine levels was investigated. 2. Animals were subjected to a daily period of isolation (9 min) and sacrificed on days 1, 2, 4, and 5. 3. In brain and cerebellum the levels of both inhibitory activities were found to be significantly(More)
We performed a double blind randomized study in order to assess the efficacy of a multivitamin supplement for the prevention of common infections in healthy elderly subjects. Non-institutionalized, independent subjects over 60 years of age, living in the Nevers area (central France) were recruited by announcements and randomly assigned to a treatment or a(More)
1. We studied the effect of isolation stress in 3- and 12-month-old rats individually housed in metabolic cages for 7 days. Urine (24 hr) was collected daily from one group of animals of each age. The other group was tested in an open field and on a hot plate on days 1 and 7. 2. Total deambulation in the open-field test was lower in young than in older rats(More)
The development of an immune suppressive microenvironment plays a primary role in the growth of tumors and represents a major obstacle in the success of tumor immunotherapy. The metabolism of the non-essential amino acid L-Arginine (L-Arg) through the enzyme arginase I in myeloid derived suppressor cells (MDSCs) is a fundamental mechanism and prime example(More)
The effects of predictable or unpredictable shocks on ambulation, pain sensitivity, plasma catecholamines and heart and brain monoamine oxidase (MAO) inhibitory activity were investigated in rats. Animals showed plasma catecholamines and heart MAO inhibitory activity sensitization irrespective of type of treatment, while differences between groups were(More)
  • 1