Audrey C. Muguet-Chanoit

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4-Aminopyridine (4-AP) blocks voltage gated potassium channels, restoring conduction to demyelinated axons and improving function in demyelinating conditions, but its use is associated with adverse effects and benefit in spinal cord injury is limited. Derivatives of 4-AP have been developed to improve clinical efficacy while reducing toxicity. We compared(More)
BACKGROUND An inexpensive method of generating continuous data on hind limb function in dogs with spinal cord injury is needed to facilitate multicentre clinical trials. This study aimed to define normal fore limb, hind limb coordination in dogs walking on a treadmill and then to determine whether reliable data could be generated on the frequency of hind(More)
OBJECTIVE To describe the cutaneous trunci muscle (CTM) reflex in dogs. STUDY DESIGN Prospective descriptive study. ANIMALS Normal dogs (n = 155) and 10 dogs with thoracolumbar myelopathies. METHODS The CTM reflex caudal border was assessed from the ilial crests moving cranially until a CTM contraction was elicited. The lateral borders were evaluated(More)
OBJECTIVE To determine whether changes in the cutaneous trunci muscle (CTM) reflex are an early predictor of outcome in dogs with severe acute thoracolumbar intervertebral disc extrusion (IVDE). STUDY DESIGN Multicenter prospective cohort study. ANIMALS Dogs (n = 36) with acute IVDE causing paraplegia, loss of nociception in pelvic limbs and tail, and(More)
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