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- Publications
- Influence
Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking
- Aubrey V. Weigel, Blair Simon, M. Tamkun, D. Krapf
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 4 April 2011
Diffusion in the plasma membrane of living cells is often found to display anomalous dynamics. However, the mechanism underlying this diffusion pattern remains highly controversial. Here, we study… Expand
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
- Jonathon Nixon-Abell, C. J. Obara, +9 authors J. Lippincott-Schwartz
- Chemistry, Medicine
- Science
- 28 October 2016
A dynamic view of the endoplasmic reticulum The endoplasmic reticulum (ER) is a complex membranous structure that extends from the nuclear envelope to the cell periphery. It has important roles in… Expand
Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
- Chi-Lun Chang, Aubrey V. Weigel, +8 authors J. Lippincott-Schwartz
- Chemistry, Biology
- 14 February 2019
Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a… Expand
Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules
- Aubrey V. Weigel, M. Tamkun, D. Krapf
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 11 November 2013
Significance Clathrin-mediated endocytosis is the primary pathway of cargo internalization in mammalian cells. However, little is known about the time-dependent interactions between the endocytic… Expand
Kv2.1 cell surface clusters are insertion platforms for ion channel delivery to the plasma membrane
- Emily Deutsch, Aubrey V. Weigel, +6 authors M. Tamkun
- Biology, Medicine
- Molecular biology of the cell
- 1 August 2012
Kv2.1 surface clusters in transfected HEK cells and hippocampal neurons are shown to be trafficking platforms involved in potassium channel movement to and from the cell surface. This work is the… Expand
Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs
- P. D. Fox, Christopher J. Haberkorn, +5 authors M. Tamkun
- Biology, Medicine
- Molecular biology of the cell
- 1 September 2013
This study investigates the hypothesis that trafficking of membrane proteins occurs at plasma membrane (PM) domains adjacent to underlying cortical endoplasmic reticulum (cER). The authors observe… Expand
Obstructed diffusion propagator analysis for single-particle tracking.
- Aubrey V. Weigel, S. Ragi, Michael L. Reid, E. Chong, M. Tamkun, D. Krapf
- Physics, Medicine
- Physical review. E, Statistical, nonlinear, and…
- 1 April 2012
We describe a method for the analysis of the distribution of displacements, i.e., the propagators, of single-particle tracking measurements for the case of obstructed subdiffusion in two-dimensional… Expand
Size of cell-surface Kv2.1 domains is governed by growth fluctuations.
- Aubrey V. Weigel, P. D. Fox, Elizabeth J Akin, Kari H. Ecklund, M. Tamkun, D. Krapf
- Chemistry, Medicine
- Biophysical journal
- 17 October 2012
The Kv2.1 voltage-gated potassium channel forms stable clusters on the surface of different mammalian cells. Even though these cell-surface structures have been observed for almost a decade, little… Expand
Anomalous diffusion of kv2.1 channels observed by single molecule tracking in live cells
- Aubrey V. Weigel, M. Tamkun, D. Krapf
- Chemistry, Medicine
- Annual International Conference of the IEEE…
- 11 November 2010
TLDR
Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity
- Maria S Ioannou, J. Jackson, +9 authors Z. Liu
- Biology
- 7 November 2018
HIGHLIGHTS Hyperactive neurons generate and release excess peroxidated fatty acids (FAs) Astrocytes endocytose toxic FAs as lipoprotein particles, delivering them to lipid droplets Lipid droplets… Expand