Aubrey V. Weigel

Publications31
h-index7
Citations815
Highly Influential Citations35
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Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking
Diffusion in the plasma membrane of living cells is often found to display anomalous dynamics. However, the mechanism underlying this diffusion pattern remains highly controversial. Here, we study… Expand
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Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
A dynamic view of the endoplasmic reticulum The endoplasmic reticulum (ER) is a complex membranous structure that extends from the nuclear envelope to the cell periphery. It has important roles in… Expand
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Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III
Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 Spastin, a… Expand
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Quantifying the dynamic interactions between a clathrin-coated pit and cargo molecules
Significance Clathrin-mediated endocytosis is the primary pathway of cargo internalization in mammalian cells. However, little is known about the time-dependent interactions between the endocytic… Expand
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Kv2.1 cell surface clusters are insertion platforms for ion channel delivery to the plasma membrane
Kv2.1 surface clusters in transfected HEK cells and hippocampal neurons are shown to be trafficking platforms involved in potassium channel movement to and from the cell surface. This work is the… Expand
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Plasma membrane domains enriched in cortical endoplasmic reticulum function as membrane protein trafficking hubs
This study investigates the hypothesis that trafficking of membrane proteins occurs at plasma membrane (PM) domains adjacent to underlying cortical endoplasmic reticulum (cER). The authors observe… Expand
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Obstructed diffusion propagator analysis for single-particle tracking.
We describe a method for the analysis of the distribution of displacements, i.e., the propagators, of single-particle tracking measurements for the case of obstructed subdiffusion in two-dimensional… Expand
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Size of cell-surface Kv2.1 domains is governed by growth fluctuations.
The Kv2.1 voltage-gated potassium channel forms stable clusters on the surface of different mammalian cells. Even though these cell-surface structures have been observed for almost a decade, little… Expand
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Anomalous diffusion of kv2.1 channels observed by single molecule tracking in live cells
TLDR
Kv2.1 are voltage gated potassium channels that form long-lived clusters on the surface of mammalian cells. Expand
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Neuron-astrocyte metabolic coupling during neuronal stimulation protects against fatty acid toxicity
HIGHLIGHTS Hyperactive neurons generate and release excess peroxidated fatty acids (FAs) Astrocytes endocytose toxic FAs as lipoprotein particles, delivering them to lipid droplets Lipid droplets… Expand
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