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A combination of analytical and statistical methods is used to improve a tablet coating process guided by quality by design (QbD) principles. A solid dosage form product was found to intermittently exhibit bad taste. A suspected cause was the variability in coating thickness which could lead to the subject tasting the active ingredient in some tablets. A(More)
The recent explosion of research in nanotechnology, combined with important discoveries in molecular biology, has created a new interest in biomolecular machines and robots. The main goal in the field of biomolecular machines is to use various biological elements—whose function at the cellular level creates a motion, force or a signal—as machine components(More)
Computational studies are performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH enivronment. The conformational change produces a motion of about 10 nm, making(More)
A laser-induced breakdown spectroscopy-based analytical methodology is developed to study tablet coating variability in pharmaceutical tablets. The method quantifies the amount of coating on a tablet by assigning an average coating thickness score to it. When tested using samples with different amounts of coating, the coating thickness scores showed direct(More)
In this paper, a novel nanoscale protein based nano actuator concept is described. Molecular kinematic computational tools are developed and included in our Matlab Biokinematics Toolbox to study the protein nanomotor’s performance using geometric criteria. The computational tools include the development of the molecular motor direct and inverse kinematics(More)
Dynamic and kinematic analysis is performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH environment. The conformational change produces a motion of about 10 nm,(More)
Neolamarckia cadamba is one of such ayurvedic remedy that has been mentioned in many Indian medicinal literatures. This article discusses about the medicinal values of Neolamarckia cadamba. In this communication, we reviewed the morphology, microscopy, phytochemistry of Neolamarckia cadamba and its application in the treatment of various ailments like(More)
A new nanoscale biomolecular motor is introduced: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when a virus tries to infect a cell by the process of membrane fusion. By developing similar proteins in vitro and subjecting them to appropriate conditions, similar(More)