Atul Dubey

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A combination of analytical and statistical methods is used to improve a tablet coating process guided by quality by design (QbD) principles. A solid dosage form product was found to intermittently exhibit bad taste. A suspected cause was the variability in coating thickness which could lead to the subject tasting the active ingredient in some tablets. A(More)
Computational studies are performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH enivronment. The conformational change produces a motion of about 10 nm, making(More)
Dynamic and kinematic analysis is performed to predict and verify the performance of a new nanoscale biomolecular motor: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when subjected to a changing pH environment. The conformational change produces a motion of about 10 nm,(More)
In this paper, a novel nanoscale protein based nano actuator concept is described. Molecular kinematic computational tools are developed and included in our Matlab Bioki-nematics Toolbox to study the protein nanomotor's performance using geometric criteria. The computational tools include the development of the molecular motor direct and inverse kinematics(More)
A new nanoscale biomolecular motor is introduced: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when a virus tries to infect a cell by the process of membrane fusion. By developing similar proteins in vitro and subjecting them to appropriate conditions, similar(More)
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