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Cerium oxide nanoparticles (nanoceria) have shown great potential as antioxidant and radioprotective agents for applications in cancer therapy. Recently, various polymer-coated nanoceria preparations have been developed to improve their aqueous solubility and allow for surface functionalization of these nanoparticles. However, the interaction of(More)
Recent reports indicate that cerium oxide nanoparticles (nanoceria) are potent free-radical scavengers with neuroprotective, radioprotective, and anti-inflammatory properties. Nanoceria also have the unique property of being regenerative or autocatalytic. These results point to the possibility of engineering nanoceria with selective antioxidant properties(More)
Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic(More)
The reliable and sensitive detection of cancer-specific biomarkers is important for the diagnosis and treatment of cancer. Hence, detection of these biomarkers has to be reliably and rapidly performed in diverse settings. A limitation of the conventional biomarker-screening method of enzyme-linked immunosorbent assay (ELISA) is the employment of labile(More)
Poly(ortho-phenylenediamine) synthesis enabled by the catalytic oxidase-like activity of nanoceria was accomplished for applications in electronics, medicine, and biotechnology. The polymer shows unique morphology, conductivity, and photoluminescence based on pH of the solution during synthesis. The various poly(ortho-phenylenediamine) preparations were(More)
Monitoring of microenvironmental parameters is critical in healthcare and disease management. Harnessing the antioxidant activity of nanoceria and the imaging capabilities of iron oxide nanoparticles in a device setup, we were able to image changes in the device's aqueous milieu. The device was able to convey and process changes in the microenvironment's pH(More)
Considering importance of ganglioside antibodies as biomarkers in various immune-mediated neuropathies and neurological disorders, we developed a high throughput multiplexing tool for the assessment of gangliosides-specific antibodies based on Biolpex/Luminex platform. In this report, we demonstrate that the ganglioside high throughput multiplexing tool is(More)
The development of oral sustained or controlled release dosage form of captopril has been an interested topic of research for a long period of time. Difficulties encountered on the fact that the drug is freely water soluble. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive(More)
Neutralizing antibodies induced by vaccination or natural infection play a critically important role in protection against the viral diseases. In general, neutralization of the viral infection occurs via two major pathways: pre- and post-attachment modes, the first being the most important for such infections as influenza and polio, the latter being(More)
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